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Dynamic patterning by morphogens illuminated by cis-regulatory studies

Irizarry, Jihyun and Stathopoulos, Angelike (2021) Dynamic patterning by morphogens illuminated by cis-regulatory studies. Development, 148 (2). Art. No. dev196113. ISSN 0950-1991. https://resolver.caltech.edu/CaltechAUTHORS:20210121-101410191

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Abstract

Morphogen concentration changes in space as well as over time during development. However, how these dynamics are interpreted by cells to specify fate is not well understood. Here, we focus on two morphogens: the maternal transcription factors Bicoid and Dorsal, which directly regulate target genes to pattern Drosophila embryos. The actions of these factors at enhancers has been thoroughly dissected and provides a rich platform for understanding direct input by morphogens and their changing roles over time. Importantly, Bicoid and Dorsal do not work alone; we also discuss additional inputs that work with morphogens to control spatiotemporal gene expression in embryos.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/dev.196113DOIArticle
ORCID:
AuthorORCID
Irizarry, Jihyun0000-0003-3967-2288
Stathopoulos, Angelike0000-0001-6597-2036
Additional Information:© 2021. Published by The Company of Biologists Ltd. We are grateful to Leslie Dunpiace, Susie Newcomb and Ellen Rothenberg for comments on the manuscript. The authors’ research is funded by the National Institutes of Health (R21HD095639 and R35GM118146 to A.S.). Deposited in PMC for release after 12 months. The authors declare no competing or financial interests.
Funders:
Funding AgencyGrant Number
NIHR21HD095639
NIHR35GM118146
Subject Keywords:Drosophila melanogaster; Bicoid (Bcd); Dorsal (Dl); Morphogen; Thresholds; Cis-regulatory mechanism; Gradient; Chromatin; Repressor; Activator; Enhancer; Embryonic patterning
Issue or Number:2
Record Number:CaltechAUTHORS:20210121-101410191
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210121-101410191
Official Citation:Dynamic patterning by morphogens illuminated by cis-regulatory studies Jihyun Irizarry, Angelike Stathopoulos Development 2021 148: dev196113 doi: 10.1242/dev.196113
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107623
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Jan 2021 22:25
Last Modified:21 Jan 2021 22:25

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