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The Neurophysiological Representation of Imagined Somatosensory Percepts in Human Cortex

Bashford, Luke and Rosenthal, Isabelle and Kellis, Spencer and Pejsa, Kelsie and Kramer, Daniel and Lee, Brian and Liu, Charles and Andersen, Richard A. (2021) The Neurophysiological Representation of Imagined Somatosensory Percepts in Human Cortex. Journal of Neuroscience, 41 (10). pp. 2177-2185. ISSN 0270-6474. PMCID PMC8018772. doi:10.1523/jneurosci.2460-20.2021. https://resolver.caltech.edu/CaltechAUTHORS:20210122-144955862

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Abstract

Intracortical microstimulation (ICMS) in human primary somatosensory cortex (S1) has been used to successfully evoke naturalistic sensations. However, the neurophysiological mechanisms underlying the evoked sensations remain unknown. To understand how specific stimulation parameters elicit certain sensations we must first understand the representation of those sensations in the brain. In this study we record from intracortical microelectrode arrays implanted in S1, premotor cortex, and posterior parietal cortex of a male human participant performing a somatosensory imagery task. The sensations imagined were those previously elicited by ICMS of S1, in the same array of the same participant. In both spike and local field potential recordings, features of the neural signal can be used to classify different imagined sensations. These features are shown to be stable over time. The sensorimotor cortices only encode the imagined sensation during the imagery task, while posterior parietal cortex encodes the sensations starting with cue presentation. These findings demonstrate that different aspects of the sensory experience can be individually decoded from intracortically recorded human neural signals across the cortical sensory network. Activity underlying these unique sensory representations may inform the stimulation parameters for precisely eliciting specific sensations via ICMS in future work.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.2460-20.2021DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018772PubMed CentralArticle
ORCID:
AuthorORCID
Bashford, Luke0000-0003-4391-2491
Rosenthal, Isabelle0000-0002-9791-3820
Kellis, Spencer0000-0002-5158-1058
Kramer, Daniel0000-0003-4551-2977
Lee, Brian0000-0002-3592-8146
Andersen, Richard A.0000-0002-7947-0472
Alternate Title:Somatosensory representation in human brain
Additional Information:© 2021 Bashford et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Received Sep. 19, 2020; revised Jan. 4, 2021; accepted Jan. 6, 2021. This work was supported by the National Institutes of Health National Institute of Neurological Disorders and Stroke Grant 5U01NS098975-02 (to L.B., I.R., S.K., K.P., D.K., B.L., C.L., and R.A.A.), the T&C Chen Brain-Machine Interface Center (L.B., I.R., S.K., K.P., and R.A.A.), the USC Neurorestoration Center (S.K., D.K., B.L., C.L.), the California Institute of Technology Biology and Biological Engineering Postdoctoral Fellowship (L.B.), and the James G. Boswell Foundation (R.A.A.). We thank the continued contribution from our study participant F.G. Author contributions: L.B., I.R., S.K., K.P., and R.A.A. designed research; L.B. and I.R. performed research; L.B., I.R., S.K., D.K., B.L., and C.L. contributed unpublished reagents/analytic tools; L.B. and I.R. analyzed data; L.B., I.R., S.K., and R.A.A. wrote the paper. The authors declare no competing financial interests.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIH5U01NS098975-02
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
University of Southern CaliforniaUNSPECIFIED
Caltech Division of Biology and Biological EngineeringUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:brain-machine interface; human; intracortical microstimulation; sensation; somatosensation
Issue or Number:10
PubMed Central ID:PMC8018772
DOI:10.1523/jneurosci.2460-20.2021
Record Number:CaltechAUTHORS:20210122-144955862
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210122-144955862
Official Citation:The Neurophysiological Representation of Imagined Somatosensory Percepts in Human Cortex. Luke Bashford, Isabelle Rosenthal, Spencer Kellis, Kelsie Pejsa, Daniel Kramer, Brian Lee, Charles Liu, Richard A. Andersen. Journal of Neuroscience 10 March 2021, 41 (10) 2177-2185; DOI: 10.1523/JNEUROSCI.2460-20.2021
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107666
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Jan 2021 23:22
Last Modified:19 Apr 2021 18:13

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