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Temporal isolation of neural processes underlying face preference decisions

Kim, Hackjin and Adolphs, Ralph and O'Doherty, John P. and Shimojo, Shinsuke (2007) Temporal isolation of neural processes underlying face preference decisions. Proceedings of the National Academy of Sciences of the United States of America, 104 (46). pp. 18253-18258. ISSN 0027-8424. PMCID PMC2084329. http://resolver.caltech.edu/CaltechAUTHORS:KIMpnas07b

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[img] PDF (Supplementary Figure 4. Behavioral results from preference decision task in preference-first group.) - Supplemental Material
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[img] PDF (Supporting Information Figure 5. Comparison between preference and roundness decisions in the ROIs.) - Supplemental Material
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[img] PDF (Supporting Information Figure 6. Brain responses in roundness-first group. In the roundness-first group, activity in nucleus accumbens was no longer present during preference decisions, whereas the OFC response was still present.) - Supplemental Material
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[img] PDF (Supporting Information Figure 7. Direct comparison between preference and roundness decisions.) - Supplemental Material
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[img] PDF (Supporting Information Figure 8. Gaze fixation data.) - Supplemental Material
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[img] PDF (Supporting Information Figure 9. Preference decisions made after the one-cycle.) - Supplemental Material
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[img] PDF (Supporting Information Figure 10. Chosen vs. unchosen faces during the last cycle of three-cycle trials.) - Supplemental Material
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[img] PDF (Supporting Information Figure 11. Individual vs. group preference decisions.) - Supplemental Material
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[img] PDF (Supporting Information Figure 12. Effect of preference choice vs. facial attractiveness on NAC activity.) - Supplemental Material
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[img] PDF (Supporting Information Figure 13. Reliability of preference decisions and contribution of facial attractiveness on preference decisions.) - Supplemental Material
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[img] PDF (Supporting Information Figure 14. Interaction with task.) - Supplemental Material
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PDF (Supporting Information Table 1. Brain areas involved in preference (from preference-first group) and roundness (from roundness-first group).) - Supplemental Material
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Abstract

Decisions about whether we like someone are often made so rapidly from first impressions that it is difficult to examine the engagement of neural structures at specific points in time. Here, we used a temporally extended decision-making paradigm to examine brain activation with functional MRI (fMRI) at sequential stages of the decision-making process. Activity in reward-related brain structures—the nucleus accumbens (NAC) and orbitofrontal cortex (OFC)—was found to occur at temporally dissociable phases while subjects decided which of two unfamiliar faces they preferred. Increases in activation in the OFC occurred late in the trial, consistent with a role for this area in computing the decision of which face to choose. Signal increases in the NAC occurred early in the trial, consistent with a role for this area in initial preference formation. Moreover, early signal increases in the NAC also occurred while subjects performed a control task (judging face roundness) when these data were analyzed on the basis of which of those faces were subsequently chosen as preferred in a later task. The findings support a model in which rapid, automatic engagement of the NAC conveys a preference signal to the OFC, which in turn is used to guide choice.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084329/PubMed CentralArticle
https://dx.doi.org/10.1073/pnas.0711498105DOIErratum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242692/PubMed CentralErratum
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2007 by the National Academy of Sciences. Edited by Dale Purves, Duke University Medical Center, Durham, NC, and approved September 25, 2007 (received for review April 4, 2007). Published online on November 7, 2007, 10.1073/pnas.0703101104. We thank Chinatsu Tosha, Michael Chang, Axel Lindner, Claudiu Simion, Harald Stoegbauer, Simone Wehling, and David Rudrauf for technical assistance. This work was supported by the Gimbel Discovery Fund for neuroscience (H.K. and J.P.O.), Japan Science and Technology Agency Exploratory Research for Advanced Technology Office (H.K. and S.S.), grants from the National Institute of Mental Health (to R.A.), and the Gordon and Betty Moore Foundation (R.A. and J.P.O.). Author contributions: H.K., R.A., J.P.O., and S.S. designed research; H.K. performed research; H.K. and J.P.O. analyzed data; and H.K., R.A., J.P.O., and S.S. wrote the paper. The authors declare no conflict of interest. This article is a PNAS Direct Submission. This article contains supporting information online at www.pnas.org/cgi/content/full/0703101104/DC1.
Subject Keywords:fMRI; nucleus accumbens; orbitofrontal cortex
Issue or Number:46
PubMed Central ID:PMC2084329
Record Number:CaltechAUTHORS:KIMpnas07b
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KIMpnas07b
Alternative URL:http://dx.doi.org/10.1073/pnas.0703101104
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10773
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Jun 2008
Last Modified:19 Oct 2018 20:19

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