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DNA Sensors Using DNA Charge Transport Chemistry

Barton, Jacqueline K. and Furst, Ariel L. and Grodick, Michael A. (2014) DNA Sensors Using DNA Charge Transport Chemistry. In: DNA in Supramolecular Chemistry and Nanotechnology. Wiley , Chichester, pp. 105-120. ISBN 9781118696880.

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This chapter describes applications of DNA charge transport (DNA CT) in sensing, illustrating how this chemistry is used for the construction of sensitive devices for biochemical applications. It talks about the models for how this sensing technology might also be applied within the cell, how Nature may take advantage of DNA CT chemistry. Electrochemical devices utilizing DNA CT have evolved over time. The first DNA CT‐based detection platforms contained only a single electrode. DNA CT platforms are advantageous for the detection of proteins that interact with DNA. The chapter focuses on a variety of proteins that bind to DNA in different ways but which can all be detected sensitively using DNA electrochemistry. DNA CT can occur over long molecular distances, is sensitive to and can be modulated by DNA‐binding proteins, and reports electrically on the integrity of DNA. This chemistry can therefore be powerfully applied in sensing.

Item Type:Book Section
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URLURL TypeDescription
Barton, Jacqueline K.0000-0001-9883-1600
Grodick, Michael A.0000-0001-6618-6731
Additional Information:© 2015 John Wiley & Sons, Ltd. Published Online: 21 June 2017; Published Print: 23 December 2014.
Subject Keywords:biochemical applications; DNA charge transport chemistry; DNA sensors; DNA‐binding proteins; DNA‐functionalized electrochemical sensors
Record Number:CaltechAUTHORS:20210202-134852557
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Official Citation:Barton, J.K., Furst, A.L. and Grodick, M.A. (2014). DNA Sensors Using DNA Charge Transport Chemistry. In DNA in Supramolecular Chemistry and Nanotechnology (eds E. Stulz and G.H. Clever).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107878
Deposited By: Tony Diaz
Deposited On:02 Feb 2021 22:32
Last Modified:16 Nov 2021 19:07

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