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In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator

Abiri, Parinaz and Duarte-Vogel, Sandra and Chou, Tzu-Chieh and Abiri, Arash and Gudapati, Varun and Yousefi, Alireza and Roustaei, Mehrdad and Chang, Chih-Chiang and Cui, Qingyu and Hsu, Jeffrey J. and Bersohn, Malcolm and Markovic, Dejan and Chen, Jun and Tai, Yu-Chong and Hsiai, Tzung K. (2021) In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator. Annals of Biomedical Engineering, 49 (9). pp. 2094-2102. ISSN 0090-6964. doi:10.1007/s10439-021-02729-8.

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Millions of patients worldwide are implanted with permanent pacemakers for the treatment of cardiac arrhythmias and conduction disorders. The increased use of these devices has established a growing clinical need to mitigate associated complications. Pacemaker leads, in particular, present the primary risks in most implants. While wireless power transfer holds great promise in eliminating implantable device leads, anatomical constraints limit efficient wireless transmission over the necessary operational range. We thereby developed a transmitter-centered control system for wireless power transfer with sufficient power for continuous cardiac pacing. Device safety was validated using a computational model of the system within an MRI-based anatomical model. The pacer was then fabricated to meet the acute constraints of the anterior cardiac vein (ACV) to enable intravascular deployment while maintaining power efficiency. Our computational model revealed the wireless system to operate at > 50 times below the tissue energy absorption safety criteria. We further demonstrated the capacity for ex vivo pacing of pig hearts at 60 beats per minute (BPM) and in vivo pacing at 120 BPM following pacer deployment in the ACV. This work thus established the capacity for wireless intravascular pacing with the potential to eliminate complications associated with current lead-based deep tissue implants.

Item Type:Article
Related URLs:
URLURL TypeDescription ReadCube access
Abiri, Parinaz0000-0002-0520-6863
Chou, Tzu-Chieh0000-0002-6074-8286
Gudapati, Varun0000-0003-0134-7236
Yousefi, Alireza0000-0002-6814-4452
Hsu, Jeffrey J.0000-0002-9971-5916
Tai, Yu-Chong0000-0001-8529-106X
Hsiai, Tzung K.0000-0003-1734-0792
Additional Information:© 2021 Biomedical Engineering Society. Received 01 July 2020; Accepted 07 January 2021; Published 03 February 2021. This work was supported by the National Institutes of Health HL118650, HL129727, HL111437, BX004356, and EB0220002 (T.K. Hsiai); GM008042 and UCLA David Geffen Scholarship (P. Abiri); University of California, Los Angeles startup support (J. Chen). No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.
Funding AgencyGrant Number
NIH Predoctoral FellowshipGM008042
Subject Keywords:Implantable pacemaker; Cardiovascular devices; Leadless pacemaker; Wireless biomedical devices; Wireless power transfer; Wireless pacemaker
Issue or Number:9
Record Number:CaltechAUTHORS:20210203-135928428
Persistent URL:
Official Citation:Abiri, P., Duarte-Vogel, S., Chou, TC. et al. In Vivo Intravascular Pacing Using a Wireless Microscale Stimulator. Ann Biomed Eng 49, 2094–2102 (2021).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107891
Deposited By: Tony Diaz
Deposited On:03 Feb 2021 22:35
Last Modified:28 Sep 2021 16:53

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