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Concept, implementations and applications of Fourier ptychography

Zheng, Guoan and Shen, Cheng and Jiang, Shaowei and Song, Pengming and Yang, Changhuei (2021) Concept, implementations and applications of Fourier ptychography. Nature Reviews Physics, 3 (3). pp. 207-223. ISSN 2522-5820. doi:10.1038/s42254-021-00280-y.

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The competition between resolution and the imaging field of view is a long-standing problem in traditional imaging systems — they can produce either an image of a small area with fine details or an image of a large area with coarse details. Fourier ptychography (FP) is an approach for tackling this intrinsic trade-off in imaging systems. It takes the challenge of high-throughput and high-resolution imaging from the domain of improving the physical limitations of optics to the domain of computation. It also enables post-measurement computational correction of optical aberrations. We present the basic concept of FP, compare it to related imaging modalities and then discuss experimental implementations, such as aperture-scanning FP, macroscopic camera-scanning FP, reflection mode, single-shot set-up, X-ray FP, speckle-scanning scheme and deep-learning-related implementations. Various applications of FP are discussed, including quantitative phase imaging in 2D and 3D, digital pathology, high-throughput cytometry, aberration metrology, long-range imaging and coherent X-ray nanoscopy. A collection of datasets and reconstruction codes is provided for readers interested in implementing FP themselves.

Item Type:Article
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URLURL TypeDescription ReadCube access ItemCode
Zheng, Guoan0000-0002-4268-2690
Shen, Cheng0000-0001-7136-4715
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2021 Springer Nature Limited. Accepted 07 January 2021; Published 10 February 2021. G.Z. acknowledges the support of NSF 1510077, NSF 2012140 and the UConn SPARK grant. P.S. acknowledges the support of the Thermo Fisher Scientific Fellowship. C.Y. acknowledges the support of the Rosen Bioengineering Center Endowment Fund (9900050). Code availability: Example Fourier ptychography codes and datasets are available at Author Contributions: G.Z. prepared the display items. S.J. prepared the initial draft of the Supplementary Note. All authors contributed to all aspects of manuscript preparation, revision and editing. The authors declare no competing interests. Peer review information: Nature Reviews Physics thanks Ashok Veeraraghavan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
Group:Rosen Bioengineering Center
Funding AgencyGrant Number
University of ConnecticutUNSPECIFIED
Thermo Fisher ScientificUNSPECIFIED
Donna and Benjamin M. Rosen Bioengineering Center9900050
Subject Keywords:Biophotonics; Imaging and sensing
Issue or Number:3
Record Number:CaltechAUTHORS:20210210-120447617
Persistent URL:
Official Citation:Zheng, G., Shen, C., Jiang, S. et al. Concept, implementations and applications of Fourier ptychography. Nat Rev Phys 3, 207–223 (2021).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107987
Deposited By: Tony Diaz
Deposited On:10 Feb 2021 20:28
Last Modified:16 Nov 2021 19:07

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