A Caltech Library Service

The N-end rule

Varshavsky, Alexander (1992) The N-end rule. Cell, 69 (5). pp. 725-735. ISSN 0092-8674. doi:10.1016/0092-8674(92)90285-k.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Since its discovery in 1986, distinct versions of the N-end rule have been shown to operate in all organisms examined, from animals and plants to yeast and bacteria. This review considers intracellular protein degradation with an emphasis on the N-end rule.

Item Type:Article
Related URLs:
URLURL TypeDescription
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 1992 Cell Press. I am greatly indebted to the past and present members of the laboratory for helpful discussions and advice. I thank B. Bartel, Ft. Baker, J. Dohmen, M. Ellison, D. Finley, M. Hochstrasser, E. Johnson, N. Johnsson, K. Madura, J. McGrath, I. Ota, J. Tobias, and P. Waker for comments on the manuscript and B. Doran for secretarial assistance. Work in the author’s laboratory is supported by grants from the National Institutes of Health.
Funding AgencyGrant Number
Issue or Number:5
Record Number:CaltechAUTHORS:20210210-151525504
Persistent URL:
Official Citation:Alexander Varshavsky, The N-end rule, Cell, Volume 69, Issue 5, 1992, Pages 725-735, ISSN 0092-8674,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107995
Deposited By: George Porter
Deposited On:10 Feb 2021 23:52
Last Modified:16 Nov 2021 19:08

Repository Staff Only: item control page