Varshavsky, Alexander (1992) The N-end rule. Cell, 69 (5). pp. 725-735. ISSN 0092-8674. doi:10.1016/0092-8674(92)90285-k. https://resolver.caltech.edu/CaltechAUTHORS:20210210-151525504
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20210210-151525504
Abstract
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Since its discovery in 1986, distinct versions of the N-end rule have been shown to operate in all organisms examined, from animals and plants to yeast and bacteria. This review considers intracellular protein degradation with an emphasis on the N-end rule.
| Item Type: | Article | ||||||
|---|---|---|---|---|---|---|---|
| Related URLs: |
| ||||||
| ORCID: |
| ||||||
| Additional Information: | © 1992 Cell Press. I am greatly indebted to the past and present members of the laboratory for helpful discussions and advice. I thank B. Bartel, Ft. Baker, J. Dohmen, M. Ellison, D. Finley, M. Hochstrasser, E. Johnson, N. Johnsson, K. Madura, J. McGrath, I. Ota, J. Tobias, and P. Waker for comments on the manuscript and B. Doran for secretarial assistance. Work in the author’s laboratory is supported by grants from the National Institutes of Health. | ||||||
| Funders: |
| ||||||
| Issue or Number: | 5 | ||||||
| DOI: | 10.1016/0092-8674(92)90285-k | ||||||
| Record Number: | CaltechAUTHORS:20210210-151525504 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20210210-151525504 | ||||||
| Official Citation: | Alexander Varshavsky, The N-end rule, Cell, Volume 69, Issue 5, 1992, Pages 725-735, ISSN 0092-8674, https://doi.org/10.1016/0092-8674(92)90285-K. | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 107995 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | George Porter | ||||||
| Deposited On: | 10 Feb 2021 23:52 | ||||||
| Last Modified: | 16 Nov 2021 19:08 |
Repository Staff Only: item control page
