Varshavsky, Alexander (1997) The ubiquitin system. Trends in Biochemical Sciences, 22 (10). pp. 383-387. ISSN 0968-0004. doi:10.1016/s0968-0004(97)01122-5. https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600310
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Abstract
Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
| Item Type: | Article | ||||||
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| Additional Information: | © 1997 Elsevier. I thank D. Finley, S. Jentsch, and K. Madura for helpful discussions, and G. Turner, L. Peck and A. Webster for comments on the manuscript. | ||||||
| Issue or Number: | 10 | ||||||
| DOI: | 10.1016/s0968-0004(97)01122-5 | ||||||
| Record Number: | CaltechAUTHORS:20210211-162600310 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600310 | ||||||
| Official Citation: | Alexander Varshavsky, The ubiquitin system, Trends in Biochemical Sciences, Volume 22, Issue 10, 1997, Pages 383-387, ISSN 0968-0004, https://doi.org/10.1016/S0968-0004(97)01122-5. | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 108024 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | George Porter | ||||||
| Deposited On: | 12 Feb 2021 15:01 | ||||||
| Last Modified: | 16 Nov 2021 19:08 |
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