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The ubiquitin system

Varshavsky, Alexander (1997) The ubiquitin system. Trends in Biochemical Sciences, 22 (10). pp. 383-387. ISSN 0968-0004. https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600310

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Abstract

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/s0968-0004(97)01122-5DOIArticle
ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 1997 Elsevier. I thank D. Finley, S. Jentsch, and K. Madura for helpful discussions, and G. Turner, L. Peck and A. Webster for comments on the manuscript.
Issue or Number:10
Record Number:CaltechAUTHORS:20210211-162600310
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600310
Official Citation:Alexander Varshavsky, The ubiquitin system, Trends in Biochemical Sciences, Volume 22, Issue 10, 1997, Pages 383-387, ISSN 0968-0004, https://doi.org/10.1016/S0968-0004(97)01122-5.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108024
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Feb 2021 15:01
Last Modified:12 Feb 2021 15:01

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