CaltechAUTHORS
  A Caltech Library Service

The N-end rule pathway of protein degradation

Varshavsky, Alexander (1997) The N-end rule pathway of protein degradation. Genes to Cells, 2 (1). pp. 13-28. ISSN 1356-9597. https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600429

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600429

Abstract

The N‐end rule relates the in vivo half‐life of a protein to the identity of its N‐terminal residue. Similar but distinct versions of the N‐end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N‐end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76‐residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N‐end rule pathway.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1046/j.1365-2443.1997.1020301.xDOIArticle
ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 1997 Blackwell Science Limited. I am grateful to the current and former members of the laboratory, whose work on the N-end rule is described in this review. I thank colleagues whose names are cited in the text for their permission to discuss unpublished data. Our studies are supported by grants from the NIH and the Association for the Cure of the Cancer of the Prostate. This article is a modified and updated version of an earlier review (Varshavsky 1996b).
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Association for the Cure of Cancer of the ProstateUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20210211-162600429
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210211-162600429
Official Citation:Varshavsky, A. (1997), The N‐end rule pathway of protein degradation. Genes to Cells, 2: 13-28. https://doi.org/10.1046/j.1365-2443.1997.1020301.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108025
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Feb 2021 16:41
Last Modified:12 Feb 2021 16:41

Repository Staff Only: item control page