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A functional logic for neurotransmitter co-release in the cholinergic forebrain pathway

Nair, Aditya and Graf, Martin and Teo, Yue Yang and Augustine, George J. (2021) A functional logic for neurotransmitter co-release in the cholinergic forebrain pathway. . (Unpublished)

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The forebrain cholinergic system has recently been shown to co-release both acetylcholine and GABA. We have discovered that such co-release by cholinergic inputs to the claustrum differentially affects neurons that project to cortical versus subcortical targets. The resulting changes in neuronal gain toggles network efficiency and discriminability of output between two different projection subcircuits. Our results provide a potential logic for neurotransmitter co-release in cholinergic systems.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper ItemCode
Nair, Aditya0000-0001-5242-5527
Augustine, George J.0000-0001-7408-7485
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. This version posted February 25, 2021. Code used for analysis of IO curves and the recurrent claustrum network is available at We thank K.L.L Wong, Z. Chia, G. X. Ham, L. Mark, and G. Silberberg for insightful discussions and comments on our paper and K. Chung, P. Teo, S. Kay, R. Tan, and Y. C. Teo for technical assistance. Supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3-1-002). A.N is supported by a National Science Scholarship awarded by the Agency of Science, Technology and Research, Singapore. The authors declare no competing financial interests.
Funding AgencyGrant Number
Ministry of Education (Singapore)MOE2017-T3-1-002
Agency for Science, Technology and Research (A*STAR)UNSPECIFIED
Subject Keywords:cholinergic, claustrum, co-release, cell-type
Record Number:CaltechAUTHORS:20210301-072433493
Persistent URL:
Official Citation:A functional logic for neurotransmitter co-release in the cholinergic forebrain pathway. Aditya Nair, Martin Graf, Yue Yang Teo, George J. Augustine. bioRxiv 2021.02.25.432623; doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108236
Deposited By: Tony Diaz
Deposited On:01 Mar 2021 17:36
Last Modified:16 Nov 2021 19:10

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