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How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence

Stretton, Jason and Walsh, Nicholas D. and Mobbs, Dean and Schweizer, Susanne and van Harmelen, Anne-Laura and Lombardo, Michael and Goodyer, Ian and Dalgleish, Tim (2021) How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence. Brain and Behavior . ISSN 2162-3279. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20210305-104716207

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Abstract

Introduction: Understanding the emotional responsivity style and neurocognitive profiles of depression‐related processes in at‐risk youth may be helpful in revealing those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult to disentangle unique and combined effects at a neurobiological level. Methods: In a population‐derived sample of 56 older adolescents (aged 17–20), we adopted partial least squares regression and correlation models to explore the relationships between multivariate biopsychosocial risks for later depression, emotional response style, and fMRI activity, to rejecting and inclusive social feedback. Results: Behaviorally, higher depressive risk was associated with both reduced negative affect following negative social feedback and reduced positive affect following positive social feedback. In response to both cues of rejection and inclusion, we observed a general neural pattern of increased cingulate, temporal, and striatal activity in the brain. Secondly, in response to rejection only, we observed a pattern of activity in ostensibly executive control‐ and emotion regulation‐related brain regions encompassing fronto‐parietal brain networks including the angular gyrus. Conclusion: The results suggest that risk for depression is associated with a pervasive emotional insensitivity in the face of positive and negative social feedback.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/brb3.2005DOIArticle
https://publons.com/publon/10.1002/brb3.2005Related ItemPeer Review
https://doi.org/10.31234/osf.io/z2ryjDOIDiscussion Paper
https://osf.io/m5ux2/OrganizationSupplementary Materials
ORCID:
AuthorORCID
Stretton, Jason0000-0002-9819-4733
Walsh, Nicholas D.0000-0002-8195-7933
Mobbs, Dean0000-0003-1175-3772
Schweizer, Susanne0000-0001-6153-8291
van Harmelen, Anne-Laura0000-0003-1108-2921
Lombardo, Michael0000-0001-6780-8619
Goodyer, Ian0000-0001-9183-0373
Dalgleish, Tim0000-0002-7304-2231
Additional Information:© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Version of Record online: 04 March 2021; Manuscript accepted: 28 November 2020; Manuscript revised: 27 November 2020; Manuscript received: 31 March 2020. The authors gratefully thank colleagues at the Department of Psychiatry, University of Cambridge and the MRC Cognition and Brain Sciences Unit, Cambridge for help during this work. This work was supported by grants from Friends of Peterhouse Medical Fund Cambridge (RG 51114), the Wellcome Trust (RG 074296), and the UK Medical Research Council (MC US A060 0019). Author Contributions: TD, IG, DM, and NW devised the study. NW and SS collected the data. JS, ML, and ALvH analyzed the data. JS and TD wrote the paper. All authors report no biomedical financial interests or potential conflict of interests. Peer Review: The peer review history for this article is available at https://publons.com/publon/10.1002/brb3.2005. Data Availability Statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Funders:
Funding AgencyGrant Number
University of CambridgeRG 51114
Wellcome TrustRG 074296
Medical Research Council (UK)MC US A060 0019
Subject Keywords:adolescence; biopsychosocial; depressive risk; emotion context insensitivity; partial least squares
Record Number:CaltechAUTHORS:20210305-104716207
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210305-104716207
Official Citation:Stretton, J, Walsh, N D, Mobbs, D, et al. How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence. Brain Behav. 2020; 00:e02005. https://doi.org/10.1002/brb3.2005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108329
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Mar 2021 23:21
Last Modified:08 Mar 2021 23:21

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