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Light-Adjustable Lens: Development of in Vitro Nomograms

Schwartz, Daniel M. and Sandstedt, Christian A. and Chang, Shiao H. and Kornfield, Julie A. and Grubbs, Robert H. (2004) Light-Adjustable Lens: Development of in Vitro Nomograms. Transactions of the American Ophthalmological Society, 102 . pp. 67-74. ISSN 1545-6110. PMCID PMC1280088.

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Purpose: To determine whether digital spatial intensity patterns can be developed to effect precise in vitro correction of myopic, hyperopic, and astigmatic refractive errors in a silicone light-adjustable lens (LAL). Also, to determine whether a new spatial intensity pattern for “lock-in” is effective in vitro. Methods: A digital interferometer/irradiation system was developed to irradiate LALs and measure the power change following irradiation. Light-adjustable lenses were mounted into a wet cell maintained at 35.0 ± 0.5°C (simulated ocular temperature) and allowed to equilibrate for a minimum of 2 hours. Ultraviolet light was then applied with spatial light intensity patterns to correct hyperopia, myopia, and astigmatism. Light-adjustable lenses were also treated to effect lock-in with a separate spatial light intensity pattern. Treated lenses were characterized for power change and optical quality. In the case of lock-in, exhaustive chemical extraction was also performed to determine the percentage of remaining macromer. Results: Appropriate digital irradiation spatial intensity patterns were created to develop nomograms for in vitro correction of myopia, hyperopia, and astigmatism in approximate 0.25 D steps. Power changes were reproducible and did not alter optical quality of the LALs. Further, lock-in dosing of the LALs did not alter optical quality or significantly change LAL power. Conclusions: In vitro nomograms have been developed for a silicone LAL that permit precise correction of myopia, hyperopia, and astigmatism. Furthermore, a spatial light intensity pattern has been devised that effects lock-in without significantly altering LAL power or optical quality.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Kornfield, Julie A.0000-0001-6746-8634
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 2004 American Ophthalmological Society. This work is supported by grant 2R44EY012181-02 from the National Eye Institute. The authors state that they have a proprietary interest in the product described in this article.
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PubMed Central ID:PMC1280088
Record Number:CaltechAUTHORS:20210309-115036488
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108367
Deposited By: Tony Diaz
Deposited On:10 Mar 2021 20:45
Last Modified:10 Mar 2021 20:45

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