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Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood

Cabeen, Ryan P. and Toga, Arthur W. and Allman, John M. (2021) Frontoinsular cortical microstructure is linked to life satisfaction in young adulthood. Brain Imaging and Behavior . ISSN 1931-7557. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20210311-090401005

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Abstract

Life satisfaction is a component of subjective wellbeing that reflects a global judgement of the quality of life according to an individual’s own needs and expectations. As a psychological construct, it has attracted attention due to its relationship to mental health, resilience to stress, and other factors. Neuroimaging studies have identified neurobiological correlates of life satisfaction; however, they are limited to functional connectivity and gray matter morphometry. We explored features of gray matter microstructure obtained through compartmental modeling of multi-shell diffusion MRI data, and we examined cortical microstructure in frontoinsular cortex in a cohort of 807 typical young adults scanned as part of the Human Connectome Project. Our experiments identified the orientation dispersion index (ODI), and analogously fractional anisotropy (FA), of frontoinsular cortex as a robust set of anatomically-specific lateralized diffusion MRI microstructure features that are linked to life satisfaction, independent of other demographic, socioeconomic, and behavioral factors. We further validated our findings in a secondary test-retest dataset and found high reliability of our imaging metrics and reproducibility of outcomes. In our analysis of twin and non-twin siblings, we found basic microstructure in frontoinsular cortex to be strongly genetically determined. We also found a more moderate but still very significant genetic role in determining microstructure as it relates to life satisfaction in frontoinsular cortex. Our findings suggest a potential linkage between well-being and microscopic features of frontoinsular cortex, which may reflect cellular morphology and architecture and may more broadly implicate the integrity of the homeostatic processing performed by frontoinsular cortex as an important component of an individual’s judgements of life satisfaction.


Item Type:Article
ORCID:
AuthorORCID
Cabeen, Ryan P.0000-0002-1372-3588
Toga, Arthur W.0000-0001-7902-3755
Additional Information:This work was supported by National Institutes of Health (grant number P41EB015922) and made possible in part by grant number 2020-225670 from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation. Data were provided in part by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Re835 search; and by the McDonnell Center for Systems Neuroscience at Washington University. The authors have no conflict of interest to report. Ethics approval: This project received approval from the University of Southern California Institutional Review Board and approval from the Human Connectome Project for Restricted Access from ConnectomeDB. Consent to participant: Written informed consent was obtained from all individual participants as part of the conduct of the Human Connectome Project. Availability of data and material: Data used in our study is available with permission from the Human Connectome Project. Our data image analysis and visualization tools available online as part of the Quantitative Imaging Toolkit (QIT).
Funders:
Funding AgencyGrant Number
NIHP41EB015922
Chan Zuckerberg Initiative2020-225670
Silicon Valley Community FoundationUNSPECIFIED
NIH1U54MH091657
Subject Keywords:subjective well-being; diffusion microstructure; frontoinsular cortex; young adulthood; von Economo neurons
Record Number:CaltechAUTHORS:20210311-090401005
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210311-090401005
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108392
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Mar 2021 17:15
Last Modified:11 Mar 2021 17:15

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