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Studies on chromatin. V. A model for the structure of chromatin subunit

Varshavsky, A. J. and Georgiev, G. P. (1975) Studies on chromatin. V. A model for the structure of chromatin subunit. Molecular Biology Reports, 2 (3). pp. 255-262. ISSN 0301-4851. doi:10.1007/bf00356996. https://resolver.caltech.edu/CaltechAUTHORS:20210317-083952421

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Abstract

A new model for the fine structure of the chromatin subunit (or ‘nucleosome’) is proposed. The model is based on previous experimental findings [1–14] and on two new suggestions, namely: (1) Eight histones form a toroidal-shaped core of the nucleosome and are arranged in the following circular sequense: . (2) DNA is ‘kinked’ around a toroidal-shaped histone core in a ‘solenoid-like’ mode, each kink occurring every 10 base pairs along DNA. The electron microscopic evidence for a toroidal shape of the nucleosome is described in the preceding paper [13]. The possibility of the existence of kinks in the DNA double helix was considered recently by Crick and Klug [14]. The proposed model of the nucleosome, being more detailed than earlier models permits us to explain in direct structural terms the yet unordered set of data bearing on the pattern of histone-histone interactions in chromatin, the results of a mild deoxyribonuclease digestion of DNA within the nucleosomal particle and also the quantitative data on the unwinding of the DNA duplex upon formation of the nucleosome.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/bf00356996DOIArticle
ORCID:
AuthorORCID
Varshavsky, A. J.0000-0002-4011-258X
Additional Information:© 1975 Springer. Received 15 August 1975.
Subject Keywords:Base Pair; Fine Structure; Quantitative Data; Experimental Finding; Early Model
Issue or Number:3
DOI:10.1007/bf00356996
Record Number:CaltechAUTHORS:20210317-083952421
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210317-083952421
Official Citation:Varshavsky, A.J., Georgiev, G.P. Studies on chromatin. V. A model for the structure of chromatin subunit. Molecular Biology Reports 2, 255–262 (1975). https://doi.org/10.1007/BF00356996
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108458
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Mar 2021 00:50
Last Modified:19 Mar 2021 00:50

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