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Transvection in the Ultrabithorax domain of the bithorax complex of Drosophila melanogaster

Mathog, David (1990) Transvection in the Ultrabithorax domain of the bithorax complex of Drosophila melanogaster. Genetics, 125 (2). pp. 371-382. ISSN 0016-6731. PMCID PMC1204026. https://resolver.caltech.edu/CaltechAUTHORS:20210318-145719750

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Abstract

The phenotypes of several heterozygous combinations of mutations which map within the Ultrabithorax gene of Drosophila melanogaster are modulated by the extent of somatic homologous chromosome pairing, an effect known as transvection. One can discriminate between otherwise phenotypically similar mutations via their transvection behavior. This suggested the existence of previously undetected intragenic functional units. A collection of mutations has been classified into "transvection groups" (in analogy to complementation groups) on the basis of transvection tests with bithorax34e, postbithorax2, and Contrabithorax1 Ultrabithorax1. The conditions necessary for each transvection effect were determined from these transvection groups. The bithorax34e mutation only transvects with Ultrabithorax mutations with a contiguous Ultrabithorax transcriptional unit. In contrast, postbithorax2 transvection requires the distal part of the bithoraxoid region. As expected, Ultrabithorax mutations do not transvect with Contrabithorax1 Ultrabithorax1. However, it appears that this cross activation is not mediated solely through one of the known regulatory regions as mutations in these regions do not consistently block the response.


Item Type:Article
Related URLs:
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https://www.genetics.org/content/125/2/371.longPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1204026PubMed CentralArticle
Additional Information:© 1990 Genetics Society of America. Manuscript received October 2, 1989; Accepted for publication February 28, 1990. I would like to thank G. MORATA (Centro de Biología Molecular, Universidad Autónoma, Madrid) and H. LIPSHITZ (Caltech, Pasadena) for providing space, proof reading, and encouragement, E. B. LEWIS and A. GARCIA-BELLIDO for providing stocks, and the referees for several helpful suggestions. This work was carried out in the laboratories of G. MORATA and H. LIPSHITZ. Funding was provided by Helen Hay Whitney Foundation and Muscular Dystrophy Association postdoctoral fellowships to D.M. and by a Developmental Biology grant from the Lucille P. Markey Charitable Trust to HOWARD D. LIPSHITZ.
Funders:
Funding AgencyGrant Number
Helen Hay Whitney FoundationUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Lucille P. Markey Charitable TrustUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC1204026
Record Number:CaltechAUTHORS:20210318-145719750
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210318-145719750
Official Citation:Transvection in the Ultrabithorax domain of the bithorax complex of Drosophila melanogaster. D Mathog. GENETICS June 1, 1990 vol. 125 no. 2 371-382
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108491
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Mar 2021 00:58
Last Modified:19 Mar 2021 00:58

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