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Cell type innovation at the tips of the animal tree

Kishi, Yuriko and Parker, Joseph (2021) Cell type innovation at the tips of the animal tree. Current Opinion in Genetics and Development, 69 . pp. 112-121. ISSN 0959-437X. doi:10.1016/j.gde.2021.01.009.

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Understanding how organs originate is challenging due to the twin problems of explaining how new cell types evolve and how collective interactions between cell types arise and become selectively advantageous. Animals are assemblages of organs and cell types of different antiquities, and among the most rapidly and convergently evolving are exocrine glands and their constituent secretory cell types. Such structures have arisen independently thousands of times across the Metazoa, impacting how animals chemically interact with their environments. The recurrent evolution of exocrine systems provides a paradigm for examining how qualitative phenotypic novelties arise from variation at the cellular level. Here, we take a hierarchical perspective, focusing on the evolutionary assembly of novel biosynthetic pathways and secretory cell types, and how both selection and non-adaptive molecular processes may combine to build the complex, modular architectures of many animal glands.

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Parker, Joseph0000-0001-9598-2454
Additional Information:© 2021 Elsevier Ltd. Available online 27 March 2021. We thank members of the Parker lab for comments on this manuscript and Udo Schmidt for permission to use images of rove beetles. This work was supported by a Rita Allen Foundation Scholars Award, a Shurl and Kay Curci Foundation grant, a Klingenstein-Simons Fellowship Award, an Alfred P. Sloan Fellowship and an NSF CAREER award (NSF 2047472) to J.P. Conflict of interest statement: Nothing declared.
Funding AgencyGrant Number
Rita Allen FoundationUNSPECIFIED
Shurl and Kay Curci FoundationUNSPECIFIED
Klingenstein-Simons FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20210329-080311133
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Official Citation:Yuriko Kishi, Joseph Parker, Cell type innovation at the tips of the animal tree, Current Opinion in Genetics & Development, Volume 69, 2021, Pages 112-121, ISSN 0959-437X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108568
Deposited By: Tony Diaz
Deposited On:30 Mar 2021 23:05
Last Modified:30 Mar 2021 23:05

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