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Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling

Renteria-Vazquez, Tiffany and Brown, Warren S. and Kang, Christine and Graves, Mark and Castelli, Fulvia and Paul, Lynn K. (2022) Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling. Journal of Autism and Developmental Disorders, 52 (2). pp. 569-583. ISSN 0162-3257. PMCID PMC9042290. doi:10.1007/s10803-021-04957-2.

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Impoverished capacity for social inference is one of several symptoms that are common to both agenesis of the corpus callosum (AgCC) and Autism Spectrum Disorder (ASD). This research compared the ability of 14 adults with AgCC, 13 high-functioning adults with ASD and 14 neurotypical controls to accurately attribute social meaning to the interactions of animated triangles. Descriptions of the animations were analyzed in three ways: subjective ratings, Linguistic Inquiry and Word Count, and topic modeling (Latent Dirichlet Allocation). Although subjective ratings indicated that all groups made similar inferences from the animations, the index of perplexity (atypicality of topic) generated from topic modeling revealed that inferences from individuals with AgCC or ASD displayed significantly less social imagination than those of controls.

Item Type:Article
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URLURL TypeDescription ReadCube access CentralArticle
Brown, Warren S.0000-0001-6142-5588
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021. Accepted 01 March 2021; Published 25 March 2021. The authors thank Dr. Ralph Adolphs and Brian Cheng for assisting with recruitment and testing of ASD participants. This research was funded in part by a Grant from Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health under Award Number R01HD092430 (LP). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Portions of this manuscript were included in the doctoral dissertations of CK and TR. Author Contributions: LP and WB designed the study. LP and CK collected the data. CK and FC administered standard scoring, MG applied Topic Modeling, and TR applied LIWC. TR, MG, CK, LP and WB analyzed the data. All authors contributed to the manuscript.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funding AgencyGrant Number
Subject Keywords:Autism; Corpus callosum; Agenesis of the corpus callosum; Social inference; Mental attribution
Issue or Number:2
PubMed Central ID:PMC9042290
Record Number:CaltechAUTHORS:20210329-092752621
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Official Citation:Renteria-Vazquez, T., Brown, W.S., Kang, C. et al. Social Inferences in Agenesis of the Corpus Callosum and Autism: Semantic Analysis and Topic Modeling. J Autism Dev Disord 52, 569–583 (2022).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108569
Deposited By: Tony Diaz
Deposited On:30 Mar 2021 23:03
Last Modified:28 Apr 2022 16:32

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