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High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions

Ma, Ru and Xia, Xinzhao and Zhang, Wei and Lu, Zhuo and Wu, Qianying and Cui, Jiangtian and Song, Hongwen and Fan, Chuan and Chen, Xueli and Wei, Junjie and Ji, Gongjun and Wang, Kai and Wang, Xiaoxiao and Qiu, Bensheng and Zhang, Xiaochu (2021) High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20210329-135647304

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Abstract

Background: Temporal interference (TI) stimulation is a new technique of noninvasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidate. Objective: To assess the effectiveness and safety aspect of the envelope-modulated waveform of TI stimulation on human primary motor cortex (M1). Methods: Participants attended three sessions of 30-min TI stimulation at 2 mA during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation. Results: In the RRTT experiment, only 70 Hz TI stimulation had a promoting effect on the reaction time (RT) performance and excitability of the motor cortex compared to sham stimulation. Meanwhile, compared with the sham condition, only 20 Hz TI stimulation significantly facilitated motor learning in the SRTT experiment, which was significantly positively correlated with the increase in motor evoked potential. Conclusion: These results indicate that the envelope-modulated waveform of TI stimulation has a significant promoting effect on human motor functions, experimentally suggesting the effectiveness of TI stimulation in humans for the first time and pave the way for further explorations.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2021.03.26.437107DOIDiscussion Paper
ORCID:
AuthorORCID
Wu, Qianying0000-0002-2665-2205
Wang, Kai0000-0002-6197-914X
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. Version 1 - March 29, 2021; Version 2 - April 13, 2021. We would like to thank Prof. Bettina Pollok for her kindly help with programming of the experimental tasks. And we thank Dr. Wei Lu for his help with circuit testing. This work was supported by grants from The National Key Basic Research Program( 2018YFC0831101), The National Natural Science Foundation of China (31771221, 71942003, 61773360, 31800927, 31900766 and 71874170), Major Project of Philosophy and Social Science Research, Ministry of Education of China (19JZD010), CAS-VPST Silk Road Science Fund 2021 (GLHZ202128), Collaborative Innovation Program of Hefei Science Center, CAS (2020HSC-CIP001). A portion of the numerical calculations in this study were performed with the supercomputing system at the Supercomputing Centre of USTC. The authors declare no conflict of interest.
Funders:
Funding AgencyGrant Number
National Key Basic Research Program of China2018YFC0831101
National Natural Science Foundation of China31771221
National Natural Science Foundation of China71942003
National Natural Science Foundation of China61773360
National Natural Science Foundation of China31800927
National Natural Science Foundation of China31900766
National Natural Science Foundation of China71874170
Ministry of Education (Taipei)19JZD010
Chinese Academy of SciencesGLHZ202128
Chinese Academy of Sciences2020HSC-CIP001
Subject Keywords:temporal interference stimulation, noninvasive brain stimulation, brain oscillation, motor function, motor cortex excitability
Record Number:CaltechAUTHORS:20210329-135647304
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210329-135647304
Official Citation:High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions. Ru Ma, Xinzhao Xia, Wei Zhang, Zhuo Lu, Qianying Wu, Jiangtian Cui, Hongwen Song, Chuan Fan, Xueli Chen, Junjie Wei, Gongjun Ji, Kai Wang, Xiaoxiao Wang, Bensheng Qiu, Xiaochu Zhang. bioRxiv 2021.03.26.437107; doi: https://doi.org/10.1101/2021.03.26.437107
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108573
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Mar 2021 18:29
Last Modified:19 Apr 2021 23:20

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