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Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum

Mangum, Ryan W. and Miller, Justin S. and Brown, Warren S. and Nolty, Anne A. T. and Paul, Lynn K. (2021) Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum. Journal of the International Neuropsychological Society, 27 (10). pp. 1037-1047. ISSN 1355-6177. PMCID PMC8744483. doi:10.1017/s1355617721000096.

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Objective: Agenesis of the corpus callosum (AgCC) is associated with a range of cognitive deficits, including mild to moderate problems in higher order executive functions evident in neuropsychological assessments. Previous research has also suggested a lack of self-awareness in persons with AgCC. Method: We investigated daily executive functioning and self-awareness in 36 individuals with AgCC by analyzing self-ratings on the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A), as well as ratings on the same instrument from close relatives. Discrepancies between self- and informant-ratings were compared to the normative sample and exploratory analyses examined possible moderating effects of participant and informant characteristics. Results: Significant deficiencies were found in the Behavioral Regulation and Metacognitive indices for both the self and informant results, with elevated frequency of metacognition scores in the borderline to clinical range. Informants also endorsed elevated frequency of borderline to clinically significant behavioral regulation scores. The proportion of AgCC participants whose self-ratings indicated less metacognitive impairment than informant-ratings was greater than in the normative sample. Self-ratings of behavioral regulation impairment decreased with age and informant-ratings of metacognition were higher in males than females. Conclusions: These findings provide evidence that individuals with AgCC experience mild to moderate executive functioning problems in everyday behavior which are observed by others. Results also suggest a lack of self-understanding or insight into the severity of these problems in the individuals with AgCC, particularly with respect to their metacognitive functioning.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Mangum, Ryan W.0000-0002-2813-8293
Brown, Warren S.0000-0001-6142-5588
Nolty, Anne A. T.0000-0002-2807-4656
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© 2021 INS. Published by Cambridge University Press. Received August 3, 2020; Final revision December 8, 2020; Accepted January 4, 2021. Published online by Cambridge University Press: 22 March 2021. Data included in this paper was also utilized in the doctoral dissertations of RM & JM, at the Fuller Graduate School of Psychology. This research was not supported by extramural funding. The authors have no conflicts of interest.
Subject Keywords:Behavioral regulation, cognitive flexibility, executive function, metacognition, self-awareness, interhemispheric commissure, BRIEF-A
Issue or Number:10
PubMed Central ID:PMC8744483
Record Number:CaltechAUTHORS:20210330-122650178
Persistent URL:
Official Citation:Mangum, R., Miller, J., Brown, W., Nolty, A., & Paul, L. (2021). Everyday Executive Function and Self-Awareness in Agenesis of the Corpus Callosum. Journal of the International Neuropsychological Society, 27(10), 1037-1047. doi:10.1017/S1355617721000096
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108583
Deposited By: Tony Diaz
Deposited On:30 Mar 2021 22:32
Last Modified:12 Jan 2022 18:38

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