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A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer

Kim, Esther and Ahn, Hyeok and Park, Hansoo (2021) A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer. Mammalian Genome . ISSN 0938-8990. doi:10.1007/s00335-021-09867-3. (In Press)

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Gut microbiota has been studied in relation to human health and disease prediction for decades. Also, immune checkpoints (ICPs) are enthusiastically investigated for anti-tumor immunotherapy. Recent studies show potential of gut microbiome and gut cytokines as biomarkers for carcinogenesis and response prediction of immune checkpoint inhibitor (ICI) response. Evidence has revealed that intestinal microorganisms play a major role in the effectiveness of programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade. In this review, we have focused on how microbiome and microbiome-generated cytokines affect immune checkpoints. We have also described the molecular mechanisms behind this interplay and the bacterial strains that have a potential role in immunotherapy.

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Park, Hansoo0000-0003-1027-8850
Additional Information:© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit Received 01 December 2020; Accepted 17 March 2021; Published 30 March 2021. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF), funded by the Ministry of Science & ICT (Grant Number: NRF-2017M3A9F3046536), a GIST Research Institute (GRI) grant, funded by the GIST in 2020. This research was supported by grants from National Cancer Centre, Korea (NCC-1911267). Author Contributions: EK and HA wrote the manuscript. HP revised the manuscript. The authors declare that they have no conflict of interest.
Funding AgencyGrant Number
National Research Foundation of KoreaNRF-2017M3A9F3046536
Gwangju Institute of Science and TechnologyUNSPECIFIED
National Cancer Centre (Korea)NCC-1911267
Record Number:CaltechAUTHORS:20210331-084638621
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Official Citation:Kim, E., Ahn, H. & Park, H. A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer. Mamm Genome (2021).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108591
Deposited By: Tony Diaz
Deposited On:09 Apr 2021 00:53
Last Modified:09 Apr 2021 00:53

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