Shang, Kuang-Ming and Komatsu, Hirotake and Tai, Yu-Chong (2021) Oxygen-Transporting Parylene-HT Mesh for Cell Transplantation to Reduce Hypoxia. In: 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE , Piscataway, NJ, pp. 458-461. ISBN 9781665419123. https://resolver.caltech.edu/CaltechAUTHORS:20210420-100830806
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Abstract
Cell transplantation is a way of treatment in which lost cellular functions can be recovered by transplanted cells. However, hypoxic conditions on the transplanted site hinder the survival of the cells. This paper presents an oxygenation device for cell transplantations to improve the engraftment and transplanted cell survival. The flexible and thin polymeric hollow mesh working as gas capillaries can effectively transport oxygen between microvessels and transplanted cells, maintaining adequate oxygen tension for cell survival and functionality. Devices are designed, fabricated, and characterized in this study. Both in silico and in vivo models demonstrate a 4-5 fold increase in cell viability compared to the control group without oxygen-transporting mesh. The results showed that a broad spectrum of cell transplantations could benefit from such MEMS oxygen-transporting device.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2021 IEEE. The authors would like to thank Drs. Colin Cook and Nicholas Scianmarello for the advice and discussion of the computational model construction. We also thank Dr. Sung Hee Kil for the critical reading and editing of the manuscript. | ||||||
| Subject Keywords: | Oxygen supply, hypoxia, cell transplantation, type 1 diabetes, pancreatic islet, Parylene-HT mesh | ||||||
| DOI: | 10.1109/mems51782.2021.9375215 | ||||||
| Record Number: | CaltechAUTHORS:20210420-100830806 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20210420-100830806 | ||||||
| Official Citation: | K. -M. Shang, H. Komatsu and Y. -C. Tai, "Oxygen-Transporting Parylene-HT Mesh for Cell Transplantation to Reduce Hypoxia," 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS), Gainesville, FL, USA, 2021, pp. 458-461, doi: 10.1109/MEMS51782.2021.9375215 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 108773 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 21 Apr 2021 17:13 | ||||||
| Last Modified: | 21 Apr 2021 17:13 |
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