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Nanophotonic sensor implants with 3D hybrid periodic-amorphous photonic crystals for wide-angle monitoring of long-term in-vivo intraocular pressure

Siddique, R. H. and Liedtke, L. and Park, H. and Lee, S. Y. and Raniwala, H. and Park, D. Y. and Lim, D. H. and Choo, H. (2020) Nanophotonic sensor implants with 3D hybrid periodic-amorphous photonic crystals for wide-angle monitoring of long-term in-vivo intraocular pressure. In: 2020 IEEE International Electron Devices Meeting (IEDM). IEEE , Piscataway, NJ, 14.5.1-14.5.4. ISBN 9781728188881. https://resolver.caltech.edu/CaltechAUTHORS:20210420-123348121

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Abstract

Glaucoma, one of the leading cause of irreversible blindness, is largely caused by an elevated intraocular pressure (IOP). However, current IOP monitoring techniques inherit major disadvantages such as imprecision, no real or long time monitoring, and difficult readout. Here, we report on a highly miniaturized (200 um thick) optomechanical nanophotonic sensor implant for long-term, continuous and on-demand IOP monitoring. This IOP sensor is made of a flexible 3D hybrid photonic crystals (HPC) that functions as a pressure-sensitive optical resonator (0.1 nm/mm Hg) and delivers IOP readings when interrogated with near-infrared light with an average accuracy of 0.56 mm Hg over the range of 0-40 mm Hg. A new fabrication process is developed using colloidal self-assembly leading to a single step formation of hybrid periodic and amorphous layers exploiting the inverse process of a drying "coffee-stain" effect. The HPC results in a wide-angle strong resonance of ±40° ensuring an easy and accurate remote and long readout distance. 8 sensors were mounted inside the anterior chamber in New Zealand white rabbits and provided continuous, accurate measurements of IOP with handheld detector for up to 6 months with no signs of inflammation.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/iedm13553.2020.9372016DOIArticle
ORCID:
AuthorORCID
Choo, H.0000-0002-8903-7939
Additional Information:© 2020 IEEE.
DOI:10.1109/IEDM13553.2020.9372016
Record Number:CaltechAUTHORS:20210420-123348121
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210420-123348121
Official Citation:R. H. Siddique et al., "Nanophotonic sensor implants with 3D hybrid periodic-amorphous photonic crystals for wide-angle monitoring of long-term in-vivo intraocular pressure," 2020 IEEE International Electron Devices Meeting (IEDM), 2020, pp. 14.5.1-14.5.4, doi: 10.1109/IEDM13553.2020.9372016
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108775
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2021 17:01
Last Modified:21 Apr 2021 17:01

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