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Total Synthesis of Complex Natural Products: More Than a Race for Molecular Summits

Reisman, Sarah E. and Maimone, Thomas J. (2021) Total Synthesis of Complex Natural Products: More Than a Race for Molecular Summits. Accounts of Chemical Research, 54 (8). pp. 1815-1816. ISSN 0001-4842. https://resolver.caltech.edu/CaltechAUTHORS:20210423-164904801

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Abstract

A particularly rich chapter in the ongoing story of organic chemistry, a field nearly two centuries old, is that of natural products total synthesis. Over the past century, total synthesis has served as a general testing ground and indicator of the capabilities of organic synthesis while also synergizing with the areas of physical organic chemistry, spectroscopy, and transition metal catalysis, among others. Many highly complex natural products, including some previously considered unfathomable as synthetic targets just decades prior, have been prepared through fully synthetic processes. Additionally, advances in stereoselective methodology and asymmetric catalysis have allowed for many highly enantioselective syntheses, a feature of significant importance for translational applications because a single enantiomer of the natural product is typically biologically active. Indeed, advances in total synthesis can be seen in multiple facets of modern-day drug discovery, whether it be complex payloads for antibody–drug conjugates, probes for target identification and mechanism of action studies, or for the synthesis of FDA-approved medicines themselves.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acs.accounts.1c00184DOIArticle
ORCID:
AuthorORCID
Reisman, Sarah E.0000-0001-8244-9300
Maimone, Thomas J.0000-0001-5823-692X
Additional Information:© The Author(s). Published 2021 by American Chemical Society. Received 18 March 2021. Published online 20 April 2021. Published in issue 20 April 2021. Guest Editorial for the Accounts of Chemical Research special issue “Total Synthesis of Natural Products”. Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.
Issue or Number:8
Record Number:CaltechAUTHORS:20210423-164904801
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210423-164904801
Official Citation:Total Synthesis of Complex Natural Products: More Than a Race for Molecular Summits. Sarah E. Reisman and Thomas J. Maimone. Accounts of Chemical Research 2021 54 (8), 1815-1816; DOI: 10.1021/acs.accounts.1c00184
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108845
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:28 Apr 2021 14:21
Last Modified:28 Apr 2021 14:31

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