Sarma, Anish A. and Sarma, Aartik and Csete, Marie and Lee, Peter P. and Doyle, John C. (2021) Control-theoretic immune tradeoffs explain SARS-CoV-2 virulence and transmission variation. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20210429-095332336
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Abstract
Dramatic variation in SARS-CoV-2 virulence and transmission between hosts has driven the COVID-19 pandemic. The complexity and dynamics of the immune response present a challenge to understanding variation in SARS-CoV-2 infections. To address this challenge, we apply control theory, a framework used to study complex feedback systems, to establish rigorous mathematical bounds on immune responses. Two mechanisms of SARS-CoV-2 biology are sufficient to create extreme variation between hosts: (1) a sparsely expressed host receptor and (2) potent, but not unique, suppression of interferon. The resulting model unifies disparate and unexplained features of the SARS-CoV-2 pandemic, predicts features of future viruses that threaten to cause pandemics, and identifies potential interventions.
Item Type: | Report or Paper (Discussion Paper) | ||||||||||
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Additional Information: | The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. This version posted April 26, 2021. | ||||||||||
Group: | COVID-19 | ||||||||||
DOI: | 10.1101/2021.04.25.441372 | ||||||||||
Record Number: | CaltechAUTHORS:20210429-095332336 | ||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20210429-095332336 | ||||||||||
Official Citation: | Control-theoretic immune tradeoffs explain SARS-CoV-2 virulence and transmission variation. Anish A. Sarma, Aartik Sarma, Marie Csete, Peter P. Lee, John C. Doyle. bioRxiv 2021.04.25.441372; doi: https://doi.org/10.1101/2021.04.25.441372 | ||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
ID Code: | 108865 | ||||||||||
Collection: | CaltechAUTHORS | ||||||||||
Deposited By: | Tony Diaz | ||||||||||
Deposited On: | 29 Apr 2021 18:25 | ||||||||||
Last Modified: | 16 Nov 2021 19:32 |
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