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Hippocampal and Orbitofrontal Theta Band Coherence Diminishes During Conflict Resolution

Tang, Austin M. and Chen, Kuang-Hsuan and Del Campo-Vera, Roberto Martin and Sebastian, Rinu and Gogia, Angad S. and Nune, George and Liu, Charles Y. and Kellis, Spencer and Lee, Brian (2021) Hippocampal and Orbitofrontal Theta Band Coherence Diminishes During Conflict Resolution. World Neurosurgery, 152 . e32-e44. ISSN 1878-8750. doi:10.1016/j.wneu.2021.04.023. https://resolver.caltech.edu/CaltechAUTHORS:20210505-081144738

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Abstract

Objective: Coherence between the hippocampus and other brain structures has been shown with the theta frequency (3–8 Hz). Cortical decreases in theta coherence are believed to reflect response accuracy efficiency. However, the role of theta coherence during conflict resolution is poorly understood in noncortical areas. In this study, coherence between the hippocampus and orbitofrontal cortex (OFC) was measured during a conflict resolution task. Although both brain areas have been previously implicated in the Stroop task, their interactions are not well understood. Methods: Nine patients were implanted with stereotactic electroencephalography contacts in the hippocampus and OFC. Local field potential data were sampled throughout discrete phases of a Stroop task. Coherence was calculated for hippocampal and OFC contact pairs, and coherence spectrograms were constructed for congruent and incongruent conditions. Coherence changes during cue processing were identified using a nonparametric cluster-permutation t test. Group analysis was conducted to compare overall theta coherence changes among conditions. Results: In 6 of 9 patients, decreased theta coherence was observed only during the incongruent condition (P < 0.05). Congruent theta coherence did not change from baseline. Group analysis showed lower theta coherence for the incongruent condition compared with the congruent condition (P < 0.05). Conclusions: Theta coherence between the hippocampus and OFC decreased during conflict. This finding supports existing theories that theta coherence desynchronization contributes to improved response accuracy and processing efficiency during conflict resolution. The underlying theta coherence observed between the hippocampus and OFC during conflict may be distinct from its previously observed role in memory.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.wneu.2021.04.023DOIArticle
ORCID:
AuthorORCID
Tang, Austin M.0000-0002-0472-9005
Del Campo-Vera, Roberto Martin0000-0001-9794-2894
Gogia, Angad S.0000-0001-8193-1824
Liu, Charles Y.0000-0001-6423-8577
Kellis, Spencer0000-0002-5158-1058
Lee, Brian0000-0002-3592-8146
Additional Information:© 2021 Elsevier Inc. Received 2 February 2021, Accepted 6 April 2021, Available online 16 April 2021. CRediT authorship contribution statement: Austin M. Tang: Methodology, Writing - original draft, Writing - review & editing. Kuang-Hsuan Chen: Methodology, Investigation, Formal analysis, Writing - original draft, Writing - review & editing. Roberto Martin Del Campo-Vera: Investigation. Rinu Sebastian: Investigation, Formal analysis. Angad S. Gogia: Writing - review & editing. George Nune: Investigation, Writing - review & editing. Charles Y. Liu: Writing - review & editing. Spencer Kellis: Methodology, Investigation, Formal analysis, Writing - original draft, Writing - review & editing. Brian Lee: Methodology, Investigation, Formal analysis, Writing - original draft, Writing - review & editing.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Subject Keywords:Coherence; Conflict processing; Orbitofrontal cortex; Stereotactic electroencephalography hippocampus; Stroop; Theta
DOI:10.1016/j.wneu.2021.04.023
Record Number:CaltechAUTHORS:20210505-081144738
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210505-081144738
Official Citation:Austin M. Tang, Kuang-Hsuan Chen, Roberto Martin Del Campo-Vera, Rinu Sebastian, Angad S. Gogia, George Nune, Charles Y. Liu, Spencer Kellis, Brian Lee, Hippocampal and Orbitofrontal Theta Band Coherence Diminishes During Conflict Resolution, World Neurosurgery, Volume 152, 2021, Pages e32-e44, ISSN 1878-8750, https://doi.org/10.1016/j.wneu.2021.04.023. (https://www.sciencedirect.com/science/article/pii/S1878875021005635)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:108972
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 May 2021 17:50
Last Modified:02 Aug 2021 17:03

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