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Schwann cell precursors: Where they come from and where they go

Solovieva, Tatiana and Bronner-Fraser, Marianne (2021) Schwann cell precursors: Where they come from and where they go. Cells & Development, 166 . Art. No. 203686. ISSN 2667-2901.

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Schwann cell precursors (SCPs) are a transient population in the embryo, closely associated with nerves along which they migrate into the periphery of the body. Long considered to be progenitors that only form Schwann cells—the myelinating cells of nerves, current evidence suggests that SCPs have much broader developmental potential. Indeed, different cell marking techniques employed over the past 20 years have identified multiple novel SCP derivatives throughout the body. It is now clear that SCPs represent a multipotent progenitor population, which also display a level of plasticity in response to injury. Moreover, they originate from multiple origins in the embryo and may reflect several distinct subpopulations in terms of molecular identity and fate. Here we review SCP origins, derivatives and plasticity in development, growth and repair.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2021 Elsevier. Received 28 February 2021, Revised 29 April 2021, Accepted 30 April 2021, Available online 3 May 2021. This work was supported by grants from the National Institutes of Health (R01DE027568 and R35NS111564). CRediT authorship contribution statement. Tatiana Solovieva and Marianne Bronner wrote the manuscript. There are no competing interests.
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Subject Keywords:Schwann cell precursor; Peripheral nervous system; Cell lineage; Neural crest
Record Number:CaltechAUTHORS:20210528-155102352
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Official Citation:Tatiana Solovieva, Marianne Bronner, Schwann cell precursors: Where they come from and where they go, Cells & Development, Volume 166, 2021, 203686, ISSN 2667-2901,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109314
Deposited By: George Porter
Deposited On:28 May 2021 23:01
Last Modified:13 Sep 2021 18:59

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