A Caltech Library Service

Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum

Wong, Kelly L. L. and Nair, Aditya and Augustine, George J. (2021) Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum. Frontiers in Neural Circuits, 15 . Art. No. 658228. ISSN 1662-5110. PMCID PMC8155375. doi:10.3389/fncir.2021.658228.

PDF - Published Version
Creative Commons Attribution.


Use this Persistent URL to link to this item:


The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum—from anatomical connectivity to behavioral manipulations—to inform future analyses of claustral function.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Nair, Aditya0000-0001-5242-5527
Augustine, George J.0000-0001-7408-7485
Additional Information:© 2021 Wong, Nair and Augustine. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 25 January 2021; Accepted: 29 March 2021; Published: 13 May 2021. We thank M. Graf, Z. Chia, G. X. Ham, and M. Zhang for insightful discussions and comments on our article. We acknowledge the Allen Brain Institute’s open access Mouse Connectivity database ( for their anatomical connectivity data. Author Contributions. All authors contributed to the article and approved the submitted version. This work was supported by the Singapore Ministry of Education under its Singapore Ministry of Education Academic Research Fund Tier 3 (MOE2017-T3-1-002). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funding AgencyGrant Number
Ministry of Education (Singapore)MOE2017-T3-1-002
Subject Keywords:claustrum, acetylcholine, serotonin, dopamine, neuromodulation
PubMed Central ID:PMC8155375
Record Number:CaltechAUTHORS:20210607-115056404
Persistent URL:
Official Citation:Wong KLL, Nair A and Augustine GJ (2021) Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum. Front. Neural Circuits 15:658228. doi: 10.3389/fncir.2021.658228
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109423
Deposited By: George Porter
Deposited On:10 Jun 2021 22:24
Last Modified:16 Nov 2021 19:36

Repository Staff Only: item control page