CaltechAUTHORS
  A Caltech Library Service

Internal state: dynamic, interconnected communication loops distributed across body, brain, and time

Kanwal, Jessleen K. and Coddington, Emma and Frazer, Rachel and Limbania, Daniela and Turner, Grace and Davila, Karla J. and Givens, Michael A. and Williams, Valarie and Datta, Sandeep Robert and Wasserman, Sara (2021) Internal state: dynamic, interconnected communication loops distributed across body, brain, and time. Integrative and Comparative Biology . ISSN 1540-7063. doi:10.1093/icb/icab101. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20210623-165526504

[img] PDF - Accepted Version
Creative Commons Attribution.

2MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20210623-165526504

Abstract

Internal state profoundly alters perception and behavior. For example, a starved fly may approach and consume foods that it would otherwise find undesirable. A socially engaged newt may remain engaged in the presence of a predator, whereas a solitary newt would otherwise attempt escape. Yet, the definition of internal state is fluid and ill-defined. As an interdisciplinary group of scholars spanning five career stages (from undergraduate to full professor) and six academic institutions, we have come together in an attempt to provide an operational definition of internal state that could be useful in understanding behavior and the function of nervous systems, at timescales relevant to the individual. In this Perspective, we propose to define internal state through an integrative framework centered on dynamic and interconnected communication loops in and between the body and the brain. This framework is informed by a synthesis of historical and contemporary paradigms used by neurobiologists, ethologists, physiologists, and endocrinologists. We view internal state as composed of both spatially distributed networks (body-brain communication loops), and temporally distributed mechanisms that weave together neural circuits, physiology, and behavior. Given the wide spatial and temporal scales at which internal state operates—and therefore the broad range of scales at which it could be defined—we choose to anchor our definition in the body. Here we focus on studies that highlight body-to-brain signaling; body represented in endocrine signaling, and brain represented in sensory signaling. This integrative framework of internal state potentially unites the disparate paradigms often used by scientists grappling with body-brain interactions. We invite others to join us as we examine approaches and question assumptions to study the underlying mechanisms and temporal dynamics of internal state.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1093/icb/icab101DOIArticle
ORCID:
AuthorORCID
Datta, Sandeep Robert0000-0002-8068-3862
Alternate Title:Internal State: body-brain communication
Additional Information:© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 11 June 2021. We would like to thank Gurdeep Pandher for giving us permission to use and annotate his Bhangra dance performance for the figure in Box 1. Recognition and thanks to Nkem Ndefo, for a more nuanced and holistic understanding of defensive behaviors and stress. The workshop on Spatiotemporal Dynamics of Animal Communication in conjunction with the 2020 Society for Integrative and Comparative Biology served as an important foundation in bringing us all together for this review article and was supported by the National Science Foundation [IOS #2010768]. Figures were made with Biorender.com. J.K.K. is supported by a Helen Hay Whitney Fellowship, E.C. is supported by the National Science Foundation [IOS #1351129], S.R.D. is supported by the National Institutes of Health [U24NS109520, RO11DC016222, U19NS113201, and RO1NS114020] and the Simons Collaboration on the Global Brain, and S.W. is supported by the National Science Foundation [IOS #2016188]. New data and availability of data: Labanotation of Bhangra phrase was generated in LabanWriter by Valarie Williams in support of this research. The data underlying this article are available in the article. We declare no conflicts of interest.
Funders:
Funding AgencyGrant Number
NSFIOS-2010768
Helen Hay Whitney FoundationUNSPECIFIED
NSFIOS-1351129
NIHU24NS109520
NIHRO11DC016222
NIHU19NS113201
NIHRO1NS114020
Simons FoundationUNSPECIFIED
NSFIOS-2016188
Subject Keywords:sensory processing, timescales, modules, endocrine, behavior, distributed network
DOI:10.1093/icb/icab101
Record Number:CaltechAUTHORS:20210623-165526504
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210623-165526504
Official Citation:Jessleen K Kanwal, Emma Coddington, Rachel Frazer, Daniela Limbania, Grace Turner, Karla J Davila, Michael A Givens, Valarie Williams, Sandeep Robert Datta, Sara Wasserman, Internal state: dynamic, interconnected communication loops distributed across body, brain, and time, Integrative and Comparative Biology, 2021, icab101, https://doi.org/10.1093/icb/icab101
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109555
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Jun 2021 17:31
Last Modified:23 Jun 2021 17:31

Repository Staff Only: item control page