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Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus

Martin del Campo-Vera, Roberto and Tang, Austin M. and Gogia, Angad S. and Chen, Kuang-Hsuan and Sebastian, Rinu and Gilbert, Zachary D. and Nune, George and Liu, Charles Y. and Kellis, Spencer and Lee, Brian (2022) Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus. Neuromodulation: Technology at the Neural Interface, 25 (2). pp. 232-244. ISSN 1094-7159. doi:10.1111/ner.13486. https://resolver.caltech.edu/CaltechAUTHORS:20210713-161310079

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Abstract

Introduction: The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13–30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. Materials and Methods: Ten epilepsy patients (5 female; ages 21–46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs posterior contacts, ipsilateral vs contralateral contacts, and male vs female beta-power values. Results: Eight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta-power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs contralateral contacts nor in anterior vs posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). Conclusion: These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/ner.13486DOIArticle
ORCID:
AuthorORCID
Martin del Campo-Vera, Roberto0000-0001-9794-2894
Tang, Austin M.0000-0002-0472-9005
Gogia, Angad S.0000-0001-8193-1824
Gilbert, Zachary D.0000-0003-4967-4383
Liu, Charles Y.0000-0001-6423-8577
Kellis, Spencer0000-0002-5158-1058
Lee, Brian0000-0002-3592-8146
Additional Information:© 2021 International Neuromodulation Society. Published by Elsevier Inc. Received 17 November 2020, Revised 8 May 2021, Accepted 1 June 2021, Available online 3 February 2022, Version of Record 3 February 2022. This work was supported by the National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health (KL2TR001854), the Tianqiao and Chrissy Chen Brain-Machine Interface Center at Caltech, the Meira and Shaul G. Massry Foundation, and the Taiwan-USC Postdoctoral Fellowship Program. Authorship Statements: Roberto Martin del Campo-Vera, Austin M. Tang, Angad S. Gogia, Spencer Kellis, and Brian Lee designed the study, including literature review and task design. Rinu Sebastian contributed to programming of the task for patient use. Statistics and analysis were performed by Roberto Martin del Campo-Vera with input from Kuang-Hsuan Chen, Spencer Kellis, and Brian Lee. Roberto Martin del Campo-Vera, Austin M. Tang, Kuang-Hsuan Chen, Zachary D. Gilbert, George Nune, Charles Y. Liu, Spencer Kellis, and Brian Lee contributed to intellectual input for the final manuscript. All authors approved the final manuscript. The authors report no conflicts of interest or financial disclosures. The highest level of ethical adherence was maintained with this manuscript.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHKL2TR001854
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
Meira and Shaul G. Massry FoundationUNSPECIFIED
Taiwan-USC Postdoctoral Fellowship ProgramUNSPECIFIED
Subject Keywords:Beta band; hippocampus; human; motor inhibition; modulation; power spectrum; stereo EEG
Issue or Number:2
DOI:10.1111/ner.13486
Record Number:CaltechAUTHORS:20210713-161310079
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210713-161310079
Official Citation:Roberto Martin del Campo-Vera, Austin M. Tang, Angad S. Gogia, Kuang-Hsuan Chen, Rinu Sebastian, Zachary D. Gilbert, George Nune, Charles Y. Liu, Spencer Kellis, Brian Lee, Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus, Neuromodulation: Technology at the Neural Interface, Volume 25, Issue 2, 2022, Pages 232-244, ISSN 1094-7159, https://doi.org/10.1111/ner.13486.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109783
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jul 2021 16:24
Last Modified:08 Feb 2022 22:34

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