CaltechAUTHORS
  A Caltech Library Service

A systematic review of next-generation point-of-care stroke diagnostic technologies

Shahrestani, Shane and Wishart, Danielle and Han, Sung Min J. and Strickland, Ben A. and Bakhsheshian, Joshua and Mack, William J. and Toga, Arthur W. and Sanossian, Nerses and Tai, Yu-Chong and Zada, Gabriel (2021) A systematic review of next-generation point-of-care stroke diagnostic technologies. Journal of Neurosurgery, 51 (1). Art. No. E11. ISSN 0022-3085. doi:10.3171/2021.4.FOCUS21122. https://resolver.caltech.edu/CaltechAUTHORS:20210713-223203001

[img] PDF - Published Version
See Usage Policy.

4MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20210713-223203001

Abstract

Objective: Stroke is a leading cause of morbidity and mortality. Current diagnostic modalities include CT and MRI. Over the last decade, novel technologies to facilitate stroke diagnosis, with the hope of shortening time to treatment and reducing rates of morbidity and mortality, have been developed. The authors conducted a systematic review to identify studies reporting on next-generation point-of-care stroke diagnostic technologies described within the last decade. Methods: A systematic review was performed according to PRISMA guidelines to identify studies reporting noninvasive stroke diagnostics. The QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) tool was utilized to assess risk of bias. PubMed, Web of Science, and Scopus databases were utilized. Primary outcomes assessed included accuracy and timing compared with standard imaging, potential risks or complications, potential limitations, cost of the technology, size/portability, and range/size of detection. Results: Of the 2646 reviewed articles, 19 studies met the inclusion criteria and included the following modalities of noninvasive stoke detection: microwave technology (6 studies, 31.6%), electroencephalography (EEG; 4 studies, 21.1%), ultrasonography (3 studies, 15.8%), near-infrared spectroscopy (NIRS; 2 studies, 10.5%), portable MRI devices (2 studies, 10.5%), volumetric impedance phase-shift spectroscopy (VIPS; 1 study, 5.3%), and eddy current damping (1 study, 5.3%). Notable medical devices that accurately predicted stroke in this review were EEG-based diagnosis, with a maximum sensitivity of 91.7% for predicting a stroke, microwave-based diagnosis, with an area under the receiver operating characteristic curve (AUC) of 0.88 for differentiating ischemic stroke and intracerebral hemorrhage (ICH), ultrasound with an AUC of 0.92, VIPS with an AUC of 0.93, and portable MRI with a diagnostic accuracy similar to that of traditional MRI. NIRS offers significant potential for more superficially located hemorrhage but is limited in detecting deep-seated ICH (2.5-cm scanning depth). Conclusions: As technology and computational resources have advanced, several novel point-of-care medical devices show promise in facilitating rapid stroke diagnosis, with the potential for improving time to treatment and informing prehospital stroke triage.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3171/2021.4.FOCUS21122DOIArticle
https://vimeo.com/557536887Related ItemVideo Abstract
ORCID:
AuthorORCID
Shahrestani, Shane0000-0001-7561-4590
Toga, Arthur W.0000-0001-7902-3755
Tai, Yu-Chong0000-0001-8529-106X
Zada, Gabriel0000-0001-5821-902X
Additional Information:© 2021 The Author(s). Author Contributions: Conception and design: Shahrestani. Acquisition of data: Shahrestani, Wishart, Han. Analysis and interpretation of data: Shahrestani, Wishart, Han. Drafting the article: Shahrestani. Critically revising the article: Shahrestani, Strickland, Bakhsheshian, Mack, Toga, Sanossian, Tai. Reviewed submitted version of manuscript: Shahrestani, Strickland, Bakhsheshian, Mack, Toga, Sanossian, Tai. Administrative/technical/material support: Zada, Tai. Study supervision: Zada, Tai. Disclosures: Dr. Mack: direct stock ownership in Integra, Cerebrotech, and Rebound Therapeutics.
Subject Keywords:eddy current damping; near-infrared spectroscopy; volumetric impedance phase-shift spectroscopy; microwave; ischemic stroke; hemorrhagic stroke
Issue or Number:1
DOI:10.3171/2021.4.FOCUS21122
Record Number:CaltechAUTHORS:20210713-223203001
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210713-223203001
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109800
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Jul 2021 22:51
Last Modified:13 Jul 2021 22:51

Repository Staff Only: item control page