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The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention

Iskander, Andrew and Bilgi, Coskun and Naftalovich, Rotem and Hacihaliloglu, Ilker and Berkman, Tolga and Naftalovich, Daniel and Pahlevan, Niema (2021) The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention. Frontiers in Bioengineering and Biotechnology, 9 . Art. No. 678048. ISSN 2296-4185. PMCID PMC8222608. doi:10.3389/fbioe.2021.678048. https://resolver.caltech.edu/CaltechAUTHORS:20210714-155706522

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Abstract

The association between blood viscosity and pathological conditions involving a number of organ systems is well known. However, how the body measures and maintains appropriate blood viscosity is not well-described. The literature endorsing the function of the carotid sinus as a site of baroreception can be traced back to some of the earliest descriptions of digital pressure on the neck producing a drop in blood delivery to the brain. For the last 30 years, improved computational fluid dynamic (CFD) simulations of blood flow within the carotid sinus have demonstrated a more nuanced understanding of the changes in the region as it relates to changes in conventional metrics of cardiovascular function, including blood pressure. We suggest that the unique flow patterns within the carotid sinus may make it an ideal site to transduce flow data that can, in turn, enable real-time measurement of blood viscosity. The recent characterization of the PIEZO receptor family in the sinus vessel wall may provide a biological basis for this characterization. When coupled with other biomarkers of cardiovascular performance and descriptions of the blood rheology unique to the sinus region, this represents a novel venue for bioinspired design that may enable end-users to manipulate and optimize blood flow.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fbioe.2021.678048DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222608PubMed CentralArticle
Additional Information:© 2021 Iskander, Bilgi, Naftalovich, Hacihaliloglu, Berkman, Naftalovich and Pahlevan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 08 March 2021; Accepted: 05 May 2021; Published: 10 June 2021. Author Contributions: AI and CB contributed to the conceptualization, writing (original draft), manuscript review, and editing. RN, TB, DN, and NP contributed to conceptualization, manuscript review, and editing. All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Subject Keywords:baroreceptor, blood flow, viscosity, PIEZO receptor, carotid sinus
PubMed Central ID:PMC8222608
DOI:10.3389/fbioe.2021.678048
Record Number:CaltechAUTHORS:20210714-155706522
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210714-155706522
Official Citation:Iskander A, Bilgi C, Naftalovich R, Hacihaliloglu I, Berkman T, Naftalovich D and Pahlevan N (2021) The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention. Front. Bioeng. Biotechnol. 9:678048. doi: 10.3389/fbioe.2021.678048
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109808
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Jul 2021 18:12
Last Modified:14 Jul 2021 18:12

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