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Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Serra-Blasco, Maria and Radua, Joaquim and Soriano-Mas, Carles and Gómez-Benlloch, Alba and Porta-Casteràs, Daniel and Carulla-Roig, Marta and Albajes-Eizagirre, Anton and Arnone, Danilo and Klauser, Paul and Canales-Rodríguez, Eric J. and Hilbert, Kevin and Wise, Toby and Cheng, Yuqui and Kandilarova, Sevdalina and Mataix-Cols, David and Vieta, Eduard and Via, Esther and Cardoner, Narcís (2021) Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis. Neuroscience and Biobehavioral Reviews, 129 . pp. 269-281. ISSN 0149-7634. doi:10.1016/j.neubiorev.2021.07.002.

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The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Item Type:Article
Related URLs:
URLURL TypeDescription
Serra-Blasco, Maria0000-0001-5793-9906
Radua, Joaquim0000-0003-1240-5438
Soriano-Mas, Carles0000-0003-4574-6597
Gómez-Benlloch, Alba0000-0001-5592-5666
Porta-Casteràs, Daniel0000-0002-3921-3607
Carulla-Roig, Marta0000-0002-0611-1145
Albajes-Eizagirre, Anton0000-0001-7767-6568
Klauser, Paul0000-0001-7900-7659
Canales-Rodríguez, Eric J.0000-0001-6421-2633
Hilbert, Kevin0000-0002-7986-4113
Wise, Toby0000-0002-9021-3282
Kandilarova, Sevdalina0000-0002-5594-4370
Mataix-Cols, David0000-0002-4545-0924
Vieta, Eduard0000-0002-0548-0053
Via, Esther0000-0002-2331-3232
Cardoner, Narcís0000-0001-9633-0888
Additional Information:© 2021 Elsevier Ltd. Received 25 January 2021, Revised 6 June 2021, Accepted 5 July 2021, Available online 10 July 2021. PK was supported by a fellowship from the Adrian and Simone Frutiger Foundation. TW was supported by an NIHR PhD studentship and a Sir Henry Wellcome postdoctoral fellowship from the Wellcome Trust. EV was supported by a Río Hortega fellowship, provided by the Carlos III Health Institute (ISCIII), Spain (CM15/000839). NC has received research scholarships from Recercaixa, the Spanish Ministry of Health, the Ministry of Science and Innovation (CIBERSAM) and the Strategic Plan for Health Research and Innovation (PERIS)2016-2020.
Funding AgencyGrant Number
Adrian and Simone Frutiger FoundationUNSPECIFIED
National Institute for Health ResearchUNSPECIFIED
Carlos III Health InstituteCM15/000839
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)UNSPECIFIED
Strategic Plan for Health Research and Innovation (PERIS)UNSPECIFIED
Subject Keywords:Major depressive disorder; Anxiety disorders; Posttraumatic stress disorder; Comorbidities; Gray matter volume; Meta-analysis; Structural neuroimaging; Neuropsychiatry
Record Number:CaltechAUTHORS:20210721-220520833
Persistent URL:
Official Citation:Maria Serra-Blasco, Joaquim Radua, Carles Soriano-Mas, Alba Gómez-Benlloch, Daniel Porta-Casteràs, Marta Carulla-Roig, Anton Albajes-Eizagirre, Danilo Arnone, Paul Klauser, Eric J. Canales-Rodríguez, Kevin Hilbert, Toby Wise, Yuqui Cheng, Sevdalina Kandilarova, David Mataix-Cols, Eduard Vieta, Esther Via, Narcís Cardoner, Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis, Neuroscience & Biobehavioral Reviews, Volume 129, 2021, Pages 269-281, ISSN 0149-7634, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:109963
Deposited By: Tony Diaz
Deposited On:26 Jul 2021 22:51
Last Modified:12 Aug 2021 21:34

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