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Photoacoustic computed tomography for functional human brain imaging [Invited]

Na, Shuai and Wang, Lihong V. (2021) Photoacoustic computed tomography for functional human brain imaging [Invited]. Biomedical Optics Express, 12 (7). pp. 4056-4083. ISSN 2156-7085. PMCID PMC8367226. doi:10.1364/boe.423707.

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The successes of magnetic resonance imaging and modern optical imaging of human brain function have stimulated the development of complementary modalities that offer molecular specificity, fine spatiotemporal resolution, and sufficient penetration simultaneously. By virtue of its rich optical contrast, acoustic resolution, and imaging depth far beyond the optical transport mean free path (∼1 mm in biological tissues), photoacoustic computed tomography (PACT) offers a promising complementary modality. In this article, PACT for functional human brain imaging is reviewed in its hardware, reconstruction algorithms, in vivo demonstration, and potential roadmap.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Na, Shuai0000-0003-2083-0047
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Received 5 Mar 2021; revised 5 Jun 2021; accepted 8 Jun 2021; published 15 Jun 2021. The authors would like to thank David C. Garrett, Yilin Luo, and Olick G. Joshua for discussing and proofreading the manuscript. This work was sponsored by the United States National Institutes of Health (NIH) grants R01 NS102213 and U01 EB029823. Disclosures: L.V.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC, and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. S.N declares no competing interests.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funding AgencyGrant Number
NIHR01 NS102213
NIHU01 EB029823
Issue or Number:7
PubMed Central ID:PMC8367226
Record Number:CaltechAUTHORS:20210803-212102564
Persistent URL:
Official Citation:Shuai Na and Lihong V. Wang, "Photoacoustic computed tomography for functional human brain imaging [Invited]," Biomed. Opt. Express 12, 4056-4083 (2021); DOI: 10.1364/boe.423707
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110140
Deposited By: Tony Diaz
Deposited On:04 Aug 2021 19:05
Last Modified:30 Aug 2021 16:16

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