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Focusing light into scattering media with ultrasound-induced field perturbation

Cheng, Zhongtao and Wang, Lihong V. (2021) Focusing light into scattering media with ultrasound-induced field perturbation. Light: Science & Applications, 10 . Art. No. 159. ISSN 2047-7538. PMCID PMC8329210. doi:10.1038/s41377-021-00605-7.

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Focusing light into scattering media, although challenging, is highly desirable in many realms. With the invention of time-reversed ultrasonically encoded (TRUE) optical focusing, acousto-optic modulation was demonstrated as a promising guidestar mechanism for achieving noninvasive and addressable optical focusing into scattering media. Here, we report a new ultrasound-assisted technique, ultrasound-induced field perturbation optical focusing, abbreviated as UFP. Unlike in conventional TRUE optical focusing, where only the weak frequency-shifted first-order diffracted photons due to acousto-optic modulation are useful, here UFP leverages the brighter zeroth-order photons diffracted by an ultrasonic guidestar as information carriers to guide optical focusing. We find that the zeroth-order diffracted photons, although not frequency-shifted, do have a field perturbation caused by the existence of the ultrasonic guidestar. By detecting and time-reversing the differential field of the frequency-unshifted photons when the ultrasound is alternately ON and OFF, we can focus light to the position where the field perturbation occurs inside the scattering medium. We demonstrate here that UFP optical focusing has superior performance to conventional TRUE optical focusing, which benefits from the more intense zeroth-order photons. We further show that UFP optical focusing can be easily and flexibly developed into double-shot realization or even single-shot realization, which is desirable for high-speed wavefront shaping. This new method upsets conventional thinking on the utility of an ultrasonic guidestar and broadens the horizon of light control in scattering media. We hope that it provides a more efficient and flexible mechanism for implementing ultrasound-guided wavefront shaping.

Item Type:Article
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URLURL TypeDescription CentralArticle
Cheng, Zhongtao0000-0002-9862-2873
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit Received 29 April 2021; Revised 16 July 2021; Accepted 20 July 2021; Published 02 August 2021. The authors appreciate Prof. James Ballard’s close reading of the paper. This work was financially supported by US National Institutes of Health (NIH) grant U01 NS099717, R35 CA220436 (Outstanding Investigator Award), and R01 EB028277. Author Contributions: Z.C. and L.V.W. conceived the concept and designed the study. Z.C. built the experimental system and performed the experiments and simulations. L.V.W. supervised the project. All authors wrote and revised the manuscript. The authors declare no competing interests.
Funding AgencyGrant Number
NIHU01 NS099717
NIHR35 CA220436
NIHR01 EB028277
Subject Keywords:Adaptive optics; Biophotonics; Imaging and sensing
PubMed Central ID:PMC8329210
Record Number:CaltechAUTHORS:20210809-152225260
Persistent URL:
Official Citation:Cheng, Z., Wang, L.V. Focusing light into scattering media with ultrasound-induced field perturbation. Light Sci Appl 10, 159 (2021).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110162
Deposited By: Tony Diaz
Deposited On:09 Aug 2021 20:27
Last Modified:09 Aug 2021 20:28

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