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Routine high-precision Nd isotope analyses: an optimized chromatographic purification scheme

Hyung, Eugenia and Tissot, François L. H. (2021) Routine high-precision Nd isotope analyses: an optimized chromatographic purification scheme. Journal of Analytical Atomic Spectrometry, 36 (9). pp. 1946-1959. ISSN 0267-9477. doi:10.1039/d1ja00169h.

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High-precision Nd isotope measurements provide key constraints on the evolution of the silicate Earth and planetary bodies. As advances in mass-spectrometry and measurement techniques have brought the precision of ¹⁴²Nd/¹⁴⁴Nd measurements down to ±2 ppm (parts-per-million), systematic biases stemming from insufficient sample purification (matrix effects and/or isobaric interferences) or non-quantitative yields are becoming increasingly problematic. One of the most widespread approaches for Nd purification uses cation-exchange column chromatography with α-HIBA (2-methylactic acid) reagent. Despite its popularity, limitations pertaining to the level of purification and yield of the α-HIBA method exist. Here we present an optimized α-HIBA purification protocol that addresses these limitations and achieves the level of purity required for routine high-precision Nd isotope analyses. This protocol builds on existing methodologies and a comprehensive series of tests that we performed, and efficiently minimizes procedural blanks, the number of column passes, and thus the sample processing time, while maximizing recovery yields. We anticipate that this optimized protocol will benefit both established and new users of the α-HIBA column chromatography method.

Item Type:Article
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URLURL TypeDescription Information Information
Hyung, Eugenia0000-0001-6635-4918
Tissot, François L. H.0000-0001-6622-2907
Additional Information:© The Royal Society of Chemistry 2021. Submitted 12 May 2021; Accepted 20 Jul 2021; First published 30 Jul 2021. The authors thank S. B. Jacobsen for useful conversations about glass column material. This work was supported by a Walter De Logi grant from Caltech for 2019–2021, NSF-EAR grant 1824002, as well as start-up funds provided by Caltech to FLHT. Author contributions: Eugenia Hyung: conceptualization, data curation, investigation, formal analysis, methodology, visualization, writing – original draft. François L. H. Tissot: conceptualization, funding acquisition, project administration, resources, supervision, validation, visualization, writing – review and editing. There are no conflicts to declare.
Funding AgencyGrant Number
Caltech De Logi FundUNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:20210823-230223521
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Official Citation:Routine high-precision Nd isotope analyses: an optimized chromatographic purification scheme. J. Anal. At. Spectrom., 2021, 36, 1946-1959; DOI: 10.1039/d1ja00169h
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110398
Deposited By: Tony Diaz
Deposited On:24 Aug 2021 17:25
Last Modified:02 Sep 2021 20:31

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