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Optical phased array neural probes for beam-steering in brain tissue

Sacher, Wesley D. and Chen, Fu-Der and Moradi-Chameh, Homeira and Liu, Xinyu and Felts Almog, Ilan and Lordello, Thomas and Chang, Michael and Naderian, Azadeh and Fowler, Trevor M. and Segev, Eran and Xue, Tianyuan and Mahallati, Sara and Valiante, Taufik A. and Moreaux, Laurent C. and Poon, Joyce K. S. and Roukes, Michael L. (2022) Optical phased array neural probes for beam-steering in brain tissue. Optics Letters, 47 (5). pp. 1073-1076. ISSN 0146-9592. doi:10.1364/OL.441609.

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Implantable silicon neural probes with integrated nanophotonic waveguides can deliver patterned dynamic illumination into brain tissue at depth. Here, we introduce neural probes with integrated optical phased arrays and demonstrate optical beam steering in vitro. Beam formation in brain tissue is simulated and characterized. The probes are used for optogenetic stimulation and calcium imaging.

Item Type:Article
Related URLs:
URLURL TypeDescription Paper
Sacher, Wesley D.0000-0003-3306-4556
Valiante, Taufik A.0000-0002-3443-3790
Moreaux, Laurent C.0000-0003-1276-5062
Poon, Joyce K. S.0000-0002-3691-4344
Roukes, Michael L.0000-0002-2916-6026
Additional Information:© 2022 Optica Publishing Group. Received 26 August 2021; revised 28 November 2021; accepted 9 December 2021; posted 13 December 2021; published 18 February 2022. Funding: National Institutes of Health (NS090596, NS099726); Caltech Kavli Nanoscience Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada. The authors declare no conflicts of interest. Data availability: Data underlying the results presented in this Letter are not publicly available at this time but may be obtained from the authors upon reasonable request.
Group:Kavli Nanoscience Institute
Funding AgencyGrant Number
Kavli Nanoscience InstituteUNSPECIFIED
Canadian Institutes of Health Research (CIHR)UNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20210831-204006744
Persistent URL:
Official Citation:Wesley D. Sacher, Fu-Der Chen, Homeira Moradi-Chameh, Xinyu Liu, Ilan Felts Almog, Thomas Lordello, Michael Chang, Azadeh Naderian, Trevor M. Fowler, Eran Segev, Tianyuan Xue, Sara Mahallati, Taufik A. Valiante, Laurent C. Moreaux, Joyce K. S. Poon, and Michael L. Roukes, "Optical phased array neural probes for beam-steering in brain tissue," Opt. Lett. 47, 1073-1076 (2022); DOI: 10.1364/OL.441609
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110665
Deposited By: George Porter
Deposited On:01 Sep 2021 14:36
Last Modified:05 Apr 2022 20:03

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