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Intracranial electrical stimulation alters meso-scale network integration as a function of network topology

Thompson, W. H. and Esteban, O. and Oya, H. and Nair, R. and Eberhardt, F. and Dubois, J. and Poldrack, R. A. and Adolphs, R. and Shine, J. M. (2021) Intracranial electrical stimulation alters meso-scale network integration as a function of network topology. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20210831-204705170

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Abstract

Human brain dynamics are organized into a multi-scale network structure that contains multiple tight-knit, meso-scale communities. Recent work has demonstrated that many psychological capacities, as well as impairments in cognitive function secondary to damage, can be mapped onto organizing principles at this mesoscopic scale. However, we still don’t know the rules that govern the dynamic interactions between regions that are constrained by the topology of the broader network. In this preregistered study, we utilized a unique human dataset in which whole brain BOLD-fMRI activity was recorded simultaneously with intracranial electrical stimulation, to characterize the effects of direct neural stimulation on the dynamic reconfiguration of the broader network. Direct neural stimulation increased the extent to which the stimulation site’s own mesoscale community integrated with the rest of the brain. Further, we found that these network changes depended on the topological role of the stimulation site itself: stimulating regions with high participation coefficients led to global integration, whereas stimulating sites with low participation coefficients integrated that regions’ own community with the rest of the brain. These findings provide direct causal evidence for how network topology shapes and constrains inter-regional coordination, and suggest applications for targeted therapeutic interventions in patients with deep-brain stimulation.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2021.01.16.426941DOIDiscussion Paper
https://openneuro.org/datasets/ds002799/versions/1.0.3Related ItemData
https://github.com/wiheto/esfmri_connectivityRelated ItemCode
ORCID:
AuthorORCID
Thompson, W. H.0000-0002-0533-6035
Esteban, O.0000-0001-8435-6191
Oya, H.0000-0002-1733-5478
Nair, R.0000-0002-8526-7948
Dubois, J.0000-0002-3029-173X
Poldrack, R. A.0000-0001-6755-0259
Adolphs, R.0000-0002-8053-9692
Shine, J. M.0000-0003-1762-5499
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license. This version posted January 19, 2021. Funded by NIH grant U01NS103780 (RP, RA), The Simons Foundation Collaboration on the Global Brain (RA), Knut and Alice Wallenberg Foundation grant 2016.0473 (WHT), National Health and Medical Research Council 1156536 (JMS), Swiss National Science Foundation PZ00P2_185872 (OE). This work was conducted on an MRI instrument funded by National Institute of Health grant 1S10OD025025-01. Code analysis: The entire code for the project can be found at https://github.com/wiheto/esfmri_connectivity under a Apache-2.0 License. Further, this repository has been linked to the preregistration at OSF, and all pull requests can be tracked seeing all the changes made.
Funders:
Funding AgencyGrant Number
NIHU01NS103780
Simons FoundationUNSPECIFIED
Knut and Alice Wallenberg Foundation2016.0473
National Health and Medical Research Council (NHMRC)1156536
Swiss National Science Foundation (SNSF)PZ00P2_185872
NIH1S10OD025025-01
DOI:10.1101/2021.01.16.426941
Record Number:CaltechAUTHORS:20210831-204705170
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210831-204705170
Official Citation:Intracranial electrical stimulation alters meso-scale network integration as a function of network topology. WH Thompson, O Esteban, H Oya, R Nair, F Eberhardt, J Dubois, RA Poldrack, R Adolphs, JM Shine. bioRxiv 2021.01.16.426941; doi: https://doi.org/10.1101/2021.01.16.426941
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110667
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Aug 2021 21:02
Last Modified:16 Nov 2021 19:41

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