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Can excitatory neuromodulation change distorted perception of one's appearance?

Wong, Wan-wa and Rangaprakash, D. and Larson, Myra S. and Diaz-Fong, Joel P. and Tadayonnejad, Reza and Leuchter, Andrew F. and Feusner, Jamie D. (2021) Can excitatory neuromodulation change distorted perception of one's appearance? Brain Stimulation, 14 (5). pp. 1197-1200. ISSN 1935-861X. doi:10.1016/j.brs.2021.07.010.

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Body dysmorphic disorder (BDD) is marked by preoccupation with misperceived appearance flaws. Previous functional magnetic resonance imaging (fMRI) studies have found reduced neural activity and connectivity of visual areas specialized for global/holistic visual processing in BDD [[1], [2], [3]], suggesting that aberrant dorsal visual system functioning might contribute to distorted perception. In this proof-of-concept study we tested if intermittent theta-burst stimulation (iTBS), a form of excitatory repetitive transcranial magnetic stimulation (rTMS), would enhance dorsal visual system utilization as quantified through dynamic effective connectivity (DEC) modeling [4]. This is a single-session study with the application of iTBS and an fMRI scan immediately afterwards (within 15 min after the stimulation). We hypothesized that those undergoing active iTBS would show enhanced connectivity in dorsal visual areas responsible for global/holistic visual processing compared with sham.

Item Type:Article
Related URLs:
URLURL TypeDescription
Wong, Wan-wa0000-0003-4829-2842
Rangaprakash, D.0000-0001-9553-1354
Larson, Myra S.0000-0001-5487-4828
Diaz-Fong, Joel P.0000-0002-2108-6830
Feusner, Jamie D.0000-0002-0391-345X
Additional Information:© 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( Received 1 July 2021, Revised 20 July 2021, Accepted 22 July 2021, Available online 30 July 2021. This study was supported by the National Institute of Mental Health (R21MH110865 to JDF, R01MH121520 to JDF), the NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI (UL1TR001881 to JDF), and the Nathan Cumming Foundation (JDF). Author contributions: WW, MSL, and JPD were responsible for data analysis and paper writing. RD, RT, and AL contributed to the study design. JDF was responsible for clinical assessment, experimental design, and paper writing. All authors read and approved the submitted manuscript. The authors declare no conflicts of interest.
Funding AgencyGrant Number
Nathan Cumming FoundationUNSPECIFIED
Subject Keywords:Body dysmorphic disorder; Transcranial magnetic stimulation; Effective connectivity; Appearance perception distortion; Body image
Issue or Number:5
Record Number:CaltechAUTHORS:20210831-222504574
Persistent URL:
Official Citation:Wan-wa Wong, D. Rangaprakash, Myra S. Larson, Joel P. Diaz-Fong, Reza Tadayonnejad, Andrew F. Leuchter, Jamie D. Feusner, Can excitatory neuromodulation change distorted perception of one's appearance?, Brain Stimulation, Volume 14, Issue 5, 2021, Pages 1197-1200, ISSN 1935-861X,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110677
Deposited By: Tony Diaz
Deposited On:31 Aug 2021 22:40
Last Modified:16 Nov 2021 19:41

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