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Virus-cell interaction with a tumor-producing virus

Vogt, Marguerite and Dulbecco, Renato (1960) Virus-cell interaction with a tumor-producing virus. Proceedings of the National Academy of Sciences of the United States of America, 46 (3). pp. 365-370. ISSN 0027-8424. PMCID PMC222842.

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The polyoma(PY) virus or parotid tumor agent (1,2) -- a DNA-containing virus (3,4) -- is characterized by a duality of action: it produces neoplasias of various types in different species of rodents (5), and causes cell degeneration in mouse embryo tissue cultures (6). In the experiments to be reported here, it was possible to obtain in cellular cultures in vitro the oncogenic effect of the virus; this afforded the possibility of studying the relationship between the oncogenic and cytocidal effect of the virus. The results so far obtained reveal a situation novel in animal viruses and suggest the existence of a host-virus interaction with characteristics reminiscent of temperate bacteriophage.

Item Type:Article
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Additional Information:© 1960 by the National Academy of Sciences. Communicated by George W. Beadle, January 18, 1960. Aided by grants from the National Foundation and from the American Cancer Society, Inc.
Funding AgencyGrant Number
National Foundation for Infantile ParalysisUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Issue or Number:3
PubMed Central ID:PMC222842
Record Number:CaltechAUTHORS:VOGpnas60
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11071
Deposited By: Tony Diaz
Deposited On:28 Jun 2008
Last Modified:03 Oct 2019 00:15

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