Watnick, Paula I. and Dea, Phoebe and Chan, Sunney I.
(1990)
Characterization of the transverse relaxation rates in lipid bilayers.
Proceedings of the National Academy of Sciences of the United States of America, 87
(6).
pp. 2082-2086.
ISSN 0027-8424.
PMCID PMC53630.
https://resolver.caltech.edu/CaltechAUTHORS:WATpnas90
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Abstract
The 2H NMR transverse relaxation rates of a deuterated phospholipid bilayer reflect slow motions in the bilayer membrane. A study of dimyristoyl lecithin specifically deuterated at several positions of the hydrocarbon chains indicates that these motions are cooperative and are confined to the hydrocarbon chains of the lipid bilayer. However, lipid head group interactions do play an important role in modulating the properties of the cooperative fluctuations of the hydrocarbon chains (director fluctuations), as evidenced by the effects of various lipid additives on the 2H NMR transverse relaxation rates of the dimyristoyl lecithin bilayer.
| Item Type: | Article |
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| Additional Information: | © 1990 by the National Academy of Sciences.
Communicated by Harden M. McConnell, December 26, 1989.
We are indebted to M. Dea, H. Eckert, T. Handel, A. Nayeem, and J. Yesinowski for helpful discussions and assistance. This work was supported by Grants GM-22432 (to S.I.C.), GM-36132 (to P.D.), and RR-08101 (to P.D.) from the National Institutes of General Medical Sciences, U.S. Public Health Service; and Petroleum Research Fund Grant 20212-B4 (to P.D.) administered by the American Chemical Society. P.I.W. was a recipient of National Research Service Award T32 GM07616 from the National Institutes of General Medical Sciences. Access to the Southern California Regional NMR Facility at Caltech, supported by Grant CHE84-40137 from the National Science Foundation, for the NMR experiments is gratefully acknowledged. This is contribution 7974 from the Division of Chemistry and Chemical Engineering.
The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. |
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| Funders: | | Funding Agency | Grant Number |
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| NIH | GM-22432 | | NIH | GM-36132 | | NIH | RR-08101 | | National Institute of General Medical Sciences | UNSPECIFIED | | American Chemical Society Petroleum Research Fund | 20212-B4 | | NIH Predoctoral Fellowship | T32 GM07616 | | NSF | CHE84-40137 |
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| Subject Keywords: | deuterium NMR, bilayer membrane, director fluctuations |
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| Other Numbering System: | | Other Numbering System Name | Other Numbering System ID |
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| Caltech Division of Chemistry and Chemical Engineering | 7974 |
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| Issue or Number: | 6 |
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| PubMed Central ID: | PMC53630 |
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| Record Number: | CaltechAUTHORS:WATpnas90 |
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| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:WATpnas90 |
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| Alternative URL: | http://www.pnas.org/cgi/content/abstract/87/6/2082 |
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| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
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| ID Code: | 1108 |
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| Collection: | CaltechAUTHORS |
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| Deposited By: |
Tony Diaz
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| Deposited On: | 20 Dec 2005 |
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| Last Modified: | 02 Oct 2019 22:40 |
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