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From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance

Perry, Elena K. and Meirelles, Lucas A. and Newman, Dianne K. (2021) From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance. Nature Reviews Microbiology . ISSN 1740-1526. doi:10.1038/s41579-021-00620-w. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20210917-143518027

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Abstract

Secondary metabolites profoundly affect microbial physiology, metabolism and stress responses. Increasing evidence suggests that these molecules can modulate microbial susceptibility to commonly used antibiotics; however, secondary metabolites are typically excluded from standard antimicrobial susceptibility assays. This may in part account for why infections by diverse opportunistic bacteria that produce secondary metabolites often exhibit discrepancies between clinical antimicrobial susceptibility testing results and clinical treatment outcomes. In this Review, we explore which types of secondary metabolite alter antimicrobial susceptibility, as well as how and why this phenomenon occurs. We discuss examples of molecules that opportunistic and enteric pathogens either generate themselves or are exposed to from their neighbours, and the nuanced impacts these molecules can have on tolerance and resistance to certain antibiotics.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41579-021-00620-wDOIArticle
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ORCID:
AuthorORCID
Perry, Elena K.0000-0002-7151-1479
Meirelles, Lucas A.0000-0003-3194-7136
Newman, Dianne K.0000-0003-1647-1918
Additional Information:© 2021 Nature Publishing Group. Accepted 02 August 2021; Published 16 September 2021. Work in the corresponding author’s laboratory was supported by grants to D.K.N. from the NIH (1R01AI127850-01A1, 1R01HL152190-01) and the Doren Family Foundation. E.K.P. was supported by a National Science Foundation Graduate Research Fellowship under Grant No. DGE-1745301. These authors contributed equally: Elena K. Perry, Lucas A. Meirelles. Author Contributions: E.K.P., L.A.M. and D.K.N. conceived the idea. E.K.P. and L.A.M. wrote the paper. D.K.N. edited the paper. The authors declare no competing interests. Peer review information: Nature Reviews Microbiology thanks B. Luisi, who co-reviewed with Y. Ntsogo and E. Petsolari; and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
Funders:
Funding AgencyGrant Number
NIH1R01AI127850-01A1
NIH1R01HL152190-01
Doren Family FoundationUNSPECIFIED
NSF Graduate Research FellowshipDGE-1745301
Subject Keywords:Antibiotics; Soil microbiology
DOI:10.1038/s41579-021-00620-w
Record Number:CaltechAUTHORS:20210917-143518027
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210917-143518027
Official Citation:Perry, E.K., Meirelles, L.A. & Newman, D.K. From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance. Nat Rev Microbiol (2021). https://doi.org/10.1038/s41579-021-00620-w
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110925
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Sep 2021 15:34
Last Modified:17 Sep 2021 15:34

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