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Essential Roles for RNA in Shaping Nuclear Organization

Quinodoz, Sofia A. and Guttman, Mitchell (2021) Essential Roles for RNA in Shaping Nuclear Organization. Cold Spring Harbor Perspectives in Biology . ISSN 1943-0264. doi:10.1101/cshperspect.a039719. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20210921-151614850

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Abstract

It has long been proposed that nuclear RNAs might play an important role in organizing the structure of the nucleus. Initial experiments performed more than 30 years ago found that global disruption of RNA led to visible rearrangements of nuclear organization. Yet, this idea remained controversial for many years, in large part because it was unclear what specific RNAs might be involved, and which specific nuclear structures might be dependent on RNA. Over the past few years, the contributions of RNA to organizing nuclear structures have become clearer with the discovery that many nuclear bodies are enriched for specific noncoding RNAs (ncRNAs); in specific cases, ncRNAs have been shown to be essential for establishment and maintenance of these nuclear structures. More recently, many different ncRNAs have been shown to play critical roles in initiating the three-dimensional (3D) spatial organization of DNA, RNA, and protein molecules in the nucleus. These examples, combined with global imaging and genomic experiments, have begun to paint a picture of a broader role for RNA in nuclear organization and to uncover a unifying mechanism that may explain why RNA is a uniquely suited molecule for this role. In this review, we provide an overview of the history of RNA and nuclear structure and discuss key examples of RNA-mediated bodies, the global roles of ncRNAs in shaping nuclear structure, and emerging insights into mechanisms of RNA-mediated nuclear organization.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/cshperspect.a039719DOIArticle
ORCID:
AuthorORCID
Quinodoz, Sofia A.0000-0003-1862-5204
Guttman, Mitchell0000-0003-4748-9352
Additional Information:© 2021 Cold Spring Harbor Laboratory Press. Published in Advance August 16, 2021. We thank Shawna Hiley for editing, Inna-Marie Strazhnik for illustrations, and members of the Guttman Laboratory for helpful discussions.
DOI:10.1101/cshperspect.a039719
Record Number:CaltechAUTHORS:20210921-151614850
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210921-151614850
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110973
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Sep 2021 15:48
Last Modified:21 Sep 2021 15:48

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