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Seq Your Destiny: Neural Crest Fate Determination in the Genomic Era

Gandhi, Shashank and Bronner, Marianne E. (2021) Seq Your Destiny: Neural Crest Fate Determination in the Genomic Era. Annual Review of Genetics, 55 . pp. 349-376. ISSN 0066-4197. doi:10.1146/annurev-genet-071719-020954. https://resolver.caltech.edu/CaltechAUTHORS:20210922-140122706

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Abstract

Neural crest stem/progenitor cells arise early during vertebrate embryogenesis at the border of the forming central nervous system. They subsequently migrate throughout the body, eventually differentiating into diverse cell types ranging from neurons and glia of the peripheral nervous system to bones of the face, portions of the heart, and pigmentation of the skin. Along the body axis, the neural crest is heterogeneous, with different subpopulations arising in the head, neck, trunk, and tail regions, each characterized by distinct migratory patterns and developmental potential. Modern genomic approaches like single-cell RNA- and ATAC-sequencing (seq) have greatly enhanced our understanding of cell lineage trajectories and gene regulatory circuitry underlying the developmental progression of neural crest cells. Here, we discuss how genomic approaches have provided new insights into old questions in neural crest biology by elucidating transcriptional and posttranscriptional mechanisms that govern neural crest formation and the establishment of axial level identity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1146/annurev-genet-071719-020954DOIArticle
ORCID:
AuthorORCID
Gandhi, Shashank0000-0002-4081-4338
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2021 Annual Reviews. Review in Advance first posted online on September 21, 2021.
Subject Keywords:neural crest, cell fate, developmental potential, genomics, specification, neural plate border
DOI:10.1146/annurev-genet-071719-020954
Record Number:CaltechAUTHORS:20210922-140122706
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210922-140122706
Official Citation:Seq Your Destiny: Neural Crest Fate Determination in the Genomic Era. Shashank Gandhi and Marianne E. Bronner. Annual Review of Genetics 2021 55:1, 349-376; DOI: 10.1146/annurev-genet-071719-020954
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:110982
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Sep 2021 18:40
Last Modified:23 Nov 2021 21:49

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