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Single cell biology—a Keystone Symposia report

Cable, Jennifer and Elowitz, Michael B. and Domingos, Ana I. and Habib, Naomi and Itzkovitz, Shalev and Hamidzada, Homaira and Balzer, Michael S. and Yanai, Itai and Liberali, Prisca and Whited, Jessica and Streets, Aaron and Cai, Long and Stergachis, Andrew B. and Hong, Clarice Kit Yee and Keren, Leeat and Guilliams, Martin and Alon, Uri and Shalek, Alex K. and Hamel, Regan and Pfau, Sarah J. and Raj, Arjun and Quake, Stephen R. and Zhang, Nancy R. and Fan, Jean and Trapnell, Cole and Wang, Bo and Greenwald, Noah F. and Vento-Tormo, Roser and Santos, Silvia D. M. and Spencer, Sabrina L. and Garcia, Hernan G. and Arekatla, Geethika and Gaiti, Federico and Arbel-Goren, Rinat and Rulands, Steffen and Junker, Jan Philipp and Klein, Allon M. and Morris, Samantha A. and Murray, John I. and Galloway, Kate E. and Ratz, Michael and Romeike, Merrit (2021) Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506 . pp. 74-97. ISSN 0077-8923. doi:10.1111/nyas.14692.

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Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium “Single Cell Biology” to discuss advances both in single cell applications and technologies.

Item Type:Article
Related URLs:
URLURL TypeDescription
Elowitz, Michael B.0000-0002-1221-0967
Habib, Naomi0000-0002-6049-2487
Itzkovitz, Shalev0000-0003-0685-2522
Balzer, Michael S.0000-0003-0508-1260
Yanai, Itai0000-0002-8438-2741
Liberali, Prisca0000-0003-0695-6081
Whited, Jessica0000-0002-3709-6515
Streets, Aaron0000-0002-3909-8389
Cai, Long0000-0002-7154-5361
Stergachis, Andrew B.0000-0002-1299-3674
Hong, Clarice Kit Yee0000-0002-9485-1425
Keren, Leeat0000-0002-6799-6303
Guilliams, Martin0000-0003-3525-7570
Shalek, Alex K.0000-0001-5670-8778
Hamel, Regan0000-0003-0013-6226
Pfau, Sarah J.0000-0001-7528-0666
Quake, Stephen R.0000-0002-1613-0809
Fan, Jean0000-0002-0212-5451
Trapnell, Cole0000-0002-8105-4347
Greenwald, Noah F.0000-0002-7836-4379
Santos, Silvia D. M.0000-0002-2906-7888
Spencer, Sabrina L.0000-0002-5798-3007
Gaiti, Federico0000-0001-5111-8816
Arbel-Goren, Rinat0000-0002-7253-2036
Rulands, Steffen0000-0001-6398-1553
Junker, Jan Philipp0000-0002-2826-8290
Klein, Allon M.0000-0001-8913-7879
Galloway, Kate E.0000-0001-7416-3193
Ratz, Michael0000-0002-9795-8033
Romeike, Merrit0000-0002-5890-2213
Additional Information:© 2021 New York Academy of Sciences. Issue Online: 20 December 2021; Version of Record online: 03 October 2021; Manuscript accepted: 24 August 2021; Manuscript received: 24 August 2021. M.S. Balzer is supported by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grant BA 6205/2-1. M. Ratz is supported by a DFG Research Fellowship, Grant RA 2889/1-1. J. Fan is supported by the National Science Foundation, Grant No. 2047611. The authors declare no competing interests.
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)BA 6205/2-1
Deutsche Forschungsgemeinschaft (DFG)RA 2889/1-1
Subject Keywords:development; differentiation; lineage tracing; reprogramming; single cell sequencing; spatial transcriptomics
Record Number:CaltechAUTHORS:20211008-183538677
Persistent URL:
Official Citation:Cable, J., Elowitz, M.B., Domingos, A.I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M.S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A.B., Hong, C.K.Y., Keren, L., Guilliams, M., Alon, U., Shalek, A.K., Hamel, R., Pfau, S.J., Raj, A., Quake, S.R., Zhang, N.R., Fan, J., Trapnell, C., Wang, B., Greenwald, N.F., Vento-Tormo, R., Santos, S.D., Spencer, S.L., Garcia, H.G., Arekatla, G., Gaiti, F., Arbel-Goren, R., Rulands, S., Junker, J.P., Klein, A.M., Morris, S.A., Murray, J.I., Galloway, K.E., Ratz, M. and Romeike, M. (2021), Single cell biology—a Keystone Symposia report. Ann. N.Y. Acad. Sci., 1506: 74-97.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:111294
Deposited By: George Porter
Deposited On:08 Oct 2021 19:35
Last Modified:12 Jan 2022 18:33

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