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Morphology of deoxyribonucleic acid extracted from cores of vaccinia virus

Easterbrook, K. B. (1967) Morphology of deoxyribonucleic acid extracted from cores of vaccinia virus. Journal of Virology, 1 (3). pp. 643-645. ISSN 0022-538X. PMCID PMC375299.

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It has been shown recently that the outer layers of vaccinia virions can be removed selectively under mild conditions to yield a preparation that consists entirely of "cores" (K. B. Easterbrook, Ultrastruct. Res. 14:484, 1966). Since these cores can be very easily ruptured and dissolved, they would seem to offer advantages over complete virions as starting material for the extraction of unbroken genomes. This note describes results obtained in an investigation into the morphology of DNA isolated from vaccinia viral cores by further detergent treatment.

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Additional Information:© 1967 American Society for Microbiology. Received for publication 25 March 1967. The technical assistance of Margaret Freeman, who made the measurements, is gratefully acknowledged. This investigation was supported by Public Health Service International Postdoctoral Fellowship 1 F05-TW-980-01 and by Public Health Service grant 5 ROI A104229-5(VR) from the National Institute of Allergy and Infectious Diseases.
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NIH Postdoctoral Fellowship1 F05-TW-980-01
NIH5 ROI A104229-5(VR)
Issue or Number:3
PubMed Central ID:PMC375299
Record Number:CaltechAUTHORS:EASjvi67
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11165
Deposited By: Archive Administrator
Deposited On:21 Jul 2008 21:45
Last Modified:03 Oct 2019 00:16

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