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Neurons in human pre-supplementary motor area encode key computations for value-based choice

Aquino, Tomas G. and Cockburn, Jeffrey and Mamelak, Adam N. and Rutishauser, Ueli and O'Doherty, John P. (2021) Neurons in human pre-supplementary motor area encode key computations for value-based choice. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20211102-172435510

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Abstract

Adaptive behavior in real-world environments demands that choices integrate over several variables, including the novelty of the options under consideration, their expected value, and uncertainty in value estimation. We recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate to probe how integration over decision variables occurs during decision-making. In contrast to the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option, but also encoded an integrated utility signal and, subsequently, the decision itself. Conversely, post-decision related encoding of variables for the chosen option was more widely distributed and especially prominent in vmPFC. Our findings position the human preSMA as central to the implementation of value-based decisions.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2021.10.27.466000DOIDiscussion Paper
ORCID:
AuthorORCID
Cockburn, Jeffrey0000-0003-2004-8653
Mamelak, Adam N.0000-0002-4245-6431
Rutishauser, Ueli0000-0002-9207-7069
O'Doherty, John P.0000-0003-0016-3531
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. This version posted October 28, 2021. We would like to thank the members of the O’Doherty and Rutishauser labs for discussions and feedback. We thank all subjects and their families for their participation, as well as nurses and medical staff for their work. This work was supported by National Institutes of Health Grants R01DA040011 and R01MH111425 (to J.P.O.), R01MH110831 (to U.R.), and P50MH094258 (to J.P.O. and U.R.). Author Contributions: T.G.A., J.C., U.R., and J.P.O. designed the study. T.G.A. performed the experiments. T.G.A. and J.C. analyzed the data. T.G.A., J.C., A.N.M. U.R., and J.P.O. wrote the paper. A.N.M. performed surgery and supervised clinical work. Competing interests: None. Data statement: Data and code will be deposited in a public archive upon acceptance of the manuscript.
Funders:
Funding AgencyGrant Number
NIHR01DA040011
NIHR01MH111425
NIHR01MH110831
NIHP50MH094258
DOI:10.1101/2021.10.27.466000
Record Number:CaltechAUTHORS:20211102-172435510
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20211102-172435510
Official Citation:Neurons in human pre-supplementary motor area encode key computations for value-based choice. Tomas G. Aquino, Jeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser, John P. O’Doherty. bioRxiv 2021.10.27.466000; doi: https://doi.org/10.1101/2021.10.27.466000
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:111704
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Nov 2021 21:54
Last Modified:02 Nov 2021 21:54

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