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Decoding grasp and speech signals from the cortical grasp circuit in a tetraplegic human

Wandelt, Sarah K. and Kellis, Spencer and Bjånes, David A. and Pejsa, Kelsie and Lee, Brian and Liu, Charles and Andersen, Richard A. (2022) Decoding grasp and speech signals from the cortical grasp circuit in a tetraplegic human. Neuron, 110 (11). pp. 1777-1787. ISSN 0896-6273. doi:10.1016/j.neuron.2022.03.009. https://resolver.caltech.edu/CaltechAUTHORS:20211103-170317858

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Abstract

The cortical grasp network encodes planning and execution of grasps and processes spoken and written aspects of language. High-level cortical areas within this network are attractive implant sites for brain-machine interfaces (BMIs). While a tetraplegic patient performed grasp motor imagery and vocalized speech, neural activity was recorded from the supramarginal gyrus (SMG), ventral premotor cortex (PMv), and somatosensory cortex (S1). In SMG and PMv, five imagined grasps were well represented by firing rates of neuronal populations during visual cue presentation. During motor imagery, these grasps were significantly decodable from all brain areas. During speech production, SMG encoded both spoken grasp types and the names of five colors. Whereas PMv neurons significantly modulated their activity during grasping, SMG’s neural population broadly encoded features of both motor imagery and speech. Together, these results indicate that brain signals from high-level areas of the human cortex could be used for grasping and speech BMI applications.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuron.2022.03.009DOIArticle
https://doi.org/10.5281/zenodo.6330179DOIData/Code
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9186423/PubMed CentralArticle
https://doi.org/10.1101/2021.10.29.466528DOIDiscussion Paper
ORCID:
AuthorORCID
Kellis, Spencer0000-0002-5158-1058
Bjånes, David A.0000-0002-1208-5916
Lee, Brian0000-0002-3592-8146
Liu, Charles0000-0001-6423-8577
Andersen, Richard A.0000-0002-7947-0472
Additional Information:© 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 3 November 2021, Revised 1 February 2022, Accepted 8 March 2022, Available online 31 March 2022. We wish to thank L. Bashford, H. Jo, and I. Rosenthal for helpful discussions and data collection. We wish to thank our study participant F.G. for his dedication to the study which made this work possible. This research was supported by the NIH National Institute of Neurological Disorders and Stroke grant U01: U01NS098975 (S.K.W., S.K., D.A.B., K.P., C.L., and R.A.A.) and by the T&C Chen Brain-Machine Interface Center (S.K.W., D.A.B., and R.A.A.). Author contributions: S.K., S.K.W., and R.A.A. designed the study. S.K.W. and S.K. developed the experimental tasks. S.K.W., S.K., and D.A.B. analyzed the results. S.K.W., S.K., D.A.B., and R.A.A. interpreted the results and wrote the paper. K.P. coordinated regulatory requirements of clinical trials. C.L. and B.L. performed the surgery to implant the recording arrays. The authors declare no competing interests. Data and code availability: All analyses were conducted in MATLAB using previously published methods and packages. MATLAB analysis scripts and preprocessed data are available on GitHub (Grasp and speech decoding: https://doi.org/10.5281/zenodo.6330179).
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHU01NS098975
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
Subject Keywords:brain-machine interfaces; single-unit recording; grasp decoding; speech decoding; supramarginal gyrus; ventral premotor cortex; somatosensory cortex
Issue or Number:11
DOI:10.1016/j.neuron.2022.03.009
Record Number:CaltechAUTHORS:20211103-170317858
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20211103-170317858
Official Citation:Sarah K. Wandelt, Spencer Kellis, David A. Bjånes, Kelsie Pejsa, Brian Lee, Charles Liu, Richard A. Andersen, Decoding grasp and speech signals from the cortical grasp circuit in a tetraplegic human, Neuron, Volume 110, Issue 11, 2022, Pages 1777-1787.e3, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2022.03.009. (https://www.sciencedirect.com/science/article/pii/S0896627322002458)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:111726
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Nov 2021 17:50
Last Modified:28 Jun 2022 19:30

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