O’Toole, George A. and Crabbé, Aurélie and Kümmerli, Rolf and LiPuma, John J. and Bomberger, Jennifer M. and Davies, Jane C. and Limoli, Dominique and Phelan, Vanessa V. and Bliska, James B. and DePas, William H. and Dietrich, Lars E. and Hampton, Thomas H. and Hunter, Ryan and Khursigara, Cezar M. and Price-Whelan, Alexa and Ashare, Alix and Cramer, Robert A. and Goldberg, Joanna B. and Harrison, Freya and Hogan, Deborah A. and Henson, Michael A. and Madden, Dean R. and Mayers, Jared R. and Nadell, Carey and Newman, Dianne and Prince, Alice and Rivett, Damian W. and Schwartzman, Joseph D. and Schultz, Daniel and Sheppard, Donald C. and Smyth, Alan R. and Spero, Melanie A. and Stanton, Bruce A. and Turner, Paul E. and van der Gast, Chris and Whelan, Fiona J. and Whitaker, Rachel and Whiteson, Katrine (2021) Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio, 12 (5). Art. No. mBio.01763-21. ISSN 2150-7511. PMCID PMC8546538. doi:10.1128/mbio.01763-21. https://resolver.caltech.edu/CaltechAUTHORS:20211116-212551206
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Abstract
A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.
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| Additional Information: | © 2021 O’Toole et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. Published 21 September 2021. We thank the Cystic Fibrosis Foundation’s willingness to support the original, in-person version of this workshop, which needed to be canceled and rescheduled as a virtual event due to the COVID-19 pandemic. We thank Madison Leonard and Cindy Stewart of DartCF for their administrative support, Fabrice Jean-Pierre for his assistance, and the workshop session moderators (A. Crabbé, J. Bomberger, V. Phelan, J. Davies, D. Limoli, R. Kümmerli) and scribes (T. Hampton, R. Hunter, L. Dietrich, A. Price-Whelan, C. Khursigara, J. Bliska, W. DePas) for their willingness to help both the planning of and logistical support during the workshop. DartCF is supported by the NIH (P30-DK117469) and the Cystic Fibrosis Foundation Research Development Program (STANTO19R0). Additional support was provided by NIH/R01AI155424, NIH/1R01HL152190, CFF/CRAMER19GO, CIHR/PJT-156111, NIH/R35GM128690, NIH/R01DK104847, R01/NIHAI127548, CFF/TURNER19PO, NIH/R01HL136919, CFF/ASHARE21G0, NIH/R35HL18500, NIH/P20GM130454, NIHR Systematic Reviews Program, CFF/WHITEL20A0, NIH/R01AI103369, University of Nottingham Anne McLaren Fellowship, Swiss National Science Foundation/31003A_182499, MRC/MR/R001898/1, NIH/R01HL151385, NIH/R01AI155424, CFF/BOMBER21R3, CFF/SPERO19F0, NIH/R01HL136647, Paul G. Allen Frontiers Investigator Award, NIH/R01HL136647, Cystic Fibrosis Trust Strategic Research Centre Award, CF Trust/VIA078, CF Trust/VIAO77, CIHR/FDN/159902, and CFF/BOMBER18G0. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Subject Keywords: | cystic fibrosis, models, polymicrobial, airway, chronic infection | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Issue or Number: | 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PubMed Central ID: | PMC8546538 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1128/mbio.01763-21 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Record Number: | CaltechAUTHORS:20211116-212551206 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20211116-212551206 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Official Citation: | O’Toole GA, Crabbé A, Kümmerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price- Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K. 2021. Model systems to study the chronic, polymicrobial infections in cystic fibrosis: current approaches and exploring future directions. mBio 12:e01763-21. https://doi.org/10.1128/mBio.01763-21. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ID Code: | 111911 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Deposited On: | 16 Nov 2021 22:03 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified: | 16 Nov 2021 22:03 |
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