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Letting the little light of mind shine: Advances and future directions in neurochemical detection

Tjahjono, Nikki and Jin, Yihan and Hsu, Alice and Roukes, Michael and Tian, Lin (2022) Letting the little light of mind shine: Advances and future directions in neurochemical detection. Neuroscience Research, 179 . pp. 65-78. ISSN 0168-0102. doi:10.1016/j.neures.2021.11.012.

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Synaptic transmission via neurochemical release is the fundamental process that integrates and relays encoded information in the brain to regulate physiological function, cognition, and emotion. To unravel the biochemical, biophysical, and computational mechanisms of signal processing, one needs to precisely measure the neurochemical release dynamics with molecular and cell-type specificity and high resolution. Here we reviewed the development of analytical, electrochemical, and fluorescence imaging approaches to detect neurotransmitter and neuromodulator release. We discussed the advantages and practicality in implementation of each technology for ease-of-use, flexibility for multimodal studies, and challenges for future optimization. We hope this review will provide a versatile guide for tool engineering and applications for recording neurochemical release.

Item Type:Article
Related URLs:
URLURL TypeDescription
Tjahjono, Nikki0000-0002-6050-3617
Jin, Yihan0000-0001-6094-3690
Hsu, Alice0000-0001-6609-2559
Roukes, Michael0000-0002-2916-6026
Tian, Lin0000-0001-7012-6926
Additional Information:© 2021 Published by Elsevier. Received 28 November 2021, Accepted 29 November 2021, Available online 30 November 2021. We would like to thank our funding sources for supporting this work, including NIH5T32GM099608-10 (N.T.), NIAR01AG054649-05(Y.H.), NIH U01NS099726 (A.H., M.R.), NIHU01NS115579, U01NS120820 (L.T.).
Funding AgencyGrant Number
NIH Predoctoral Fellowship5T32GM099608-10
Subject Keywords:neurochemistry; microdialysis; voltammetry; genetically encoded indicators; biosensors
Record Number:CaltechAUTHORS:20211202-191325802
Persistent URL:
Official Citation:Nikki Tjahjono, Yihan Jin, Alice Hsu, Michael Roukes, Lin Tian, Letting the little light of mind shine: Advances and future directions in neurochemical detection, Neuroscience Research, Volume 179, 2022, Pages 65-78, ISSN 0168-0102,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:112168
Deposited By: George Porter
Deposited On:03 Dec 2021 15:37
Last Modified:11 Jul 2022 22:31

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