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Dynamic moment analysis of the extracellular electric field of a biologically realistic spiking neuron

Milstein, Joshua N. and Koch, Christof (2008) Dynamic moment analysis of the extracellular electric field of a biologically realistic spiking neuron. Neural Computation, 20 (8). pp. 2070-2084. ISSN 0899-7667. http://resolver.caltech.edu/CaltechAUTHORS:MILnc08

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Abstract

Based on the membrane currents generated by an action potential in a biologically realistic model of a pyramidal, hippocampal cell within rat CA1, we perform a moment expansion of the extracellular field potential. We decompose the potential into both inverse and classical moments and show that this method is a rapid and efficient way to calculate the extracellular field both near and far from the cell body. The action potential gives rise to a large quadrupole moment that contributes to the extracellular field up to distances of almost 1 cm. This method will serve as a starting point in connecting the microscopic generation of electric fields at the level of neurons to macroscopic observables such as the local field potential.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1162/neco.2008.06-07-537DOIArticle
http://www.mitpressjournals.org/doi/abs/10.1162/neco.2008.06-07-537PublisherArticle
ORCID:
AuthorORCID
Koch, Christof0000-0001-6482-8067
Additional Information:© 2008 The MIT Press. Received June 1, 2007; accepted December 28, 2007. Posted Online June 5, 2008. We thank Carl Gold for providing us with his NEURON code package. We also acknowledge support from the Swartz Foundation and NSF.
Group:Koch Laboratory (KLAB)
Funders:
Funding AgencyGrant Number
Swartz FoundationUNSPECIFIED
NSFUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:MILnc08
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MILnc08
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:11218
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:24 Jul 2008 19:19
Last Modified:25 Oct 2018 21:04

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